{"id":"W4392354197","doi":"10.1101/2024.02.28.582597","title":"Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Coastal Health; BC Cancer Agency; BC Children's Hospital; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Proteostasis; Biology; Protein aggregation; Protein degradation; Ribosomal protein; Protein folding; Cell biology; Biochemistry; RNA; Ribosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439739,0.0002083754,0.0002041179,0.0008030935,0.0001740093,0.0002921988,0.00009744016,0.0002091422,0.001100705],"category_scores_gemma":[0.0001202201,0.0001141677,0.0001729961,0.0003404258,0.0002174868,0.0001974848,0.0002322198,0.0003202381,0.0002709344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475031,"about_ca_system_score_gemma":0.00009878712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005783778,"about_ca_topic_score_gemma":0.0007065955,"domain_scores_codex":[0.9999329,0.000005169722,0.000005423921,0.00002571142,0.00001569598,0.00001497878],"domain_scores_gemma":[0.9998974,0.00001272117,0.00004113361,0.00001017591,0.00001646178,0.00002210836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001836106,0.00001124416,0.003000508,0.00002280339,0.00001589803,0.00005137657,0.00002649425,0.00004663093,0.9952099,0.00006170099,0.00006549241,0.001304318],"study_design_scores_gemma":[0.00001266267,0.000249265,0.3866153,0.0000137381,0.00006604853,0.001227593,0.0001832945,0.002479465,0.6066565,0.0006101181,0.001870731,0.00001534388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944631,0.0008210076,0.002641561,0.00004756887,0.00001136349,0.00000555131,0.001417655,0.00007145927,0.0005207262],"genre_scores_gemma":[0.9908581,0.0006211613,0.003902678,0.00005073961,0.00000992166,0.00002604946,0.002484439,0.00006263379,0.001984269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100705,"threshold_uncertainty_score":0.003682256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0289872063639309,"score_gpt":0.2823783893159672,"score_spread":0.2533911829520363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}