{"id":"W4392359459","doi":"10.1016/j.cub.2024.02.015","title":"Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence","year":2024,"lang":"en","type":"article","venue":"Current Biology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Science Foundation; European Research Council; Natural Sciences and Engineering Research Council of Canada; Neurosciences Foundation; H2020 European Research Council; American Association of University Women","keywords":"Biology; Virulence; Pathogen; Immunity; Innate immune system; Virology; Microbiology; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003939352,0.0002852777,0.0004890642,0.0003892907,0.0003029073,0.0006342041,0.0004004518,0.0007884146,0.00274729],"category_scores_gemma":[0.0005833224,0.0002403888,0.0002453936,0.0001486021,0.0008319534,0.000312209,0.0008077472,0.00125321,0.0004000764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355674,"about_ca_system_score_gemma":0.0003622347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003184722,"about_ca_topic_score_gemma":0.0008927355,"domain_scores_codex":[0.9994975,0.0001416216,0.00002105455,0.0001040525,0.0001092356,0.0001264282],"domain_scores_gemma":[0.999215,0.000169306,0.0001567982,0.0001239515,0.00004098587,0.0002939722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002089968,0.00006012761,0.00173129,0.00001387338,0.000007005593,0.00004953766,0.00001245303,0.00005055832,0.9970523,0.0002781119,0.00003935804,0.0004964208],"study_design_scores_gemma":[0.0001604855,0.003060913,0.2350467,0.00003777498,0.0001155228,0.002214909,0.0007368458,0.007057054,0.7435439,0.00313603,0.004825309,0.00006456448],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977348,0.0001526137,0.001023241,0.0001615044,0.00001698931,0.000008343563,0.00004328441,0.00002548629,0.0008337335],"genre_scores_gemma":[0.9979181,0.00005945427,0.0008244924,0.0001753874,0.00001052633,0.00001629634,0.0000689919,0.00001774383,0.0009090575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00274729,"threshold_uncertainty_score":0.009190619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915057460243686,"score_gpt":0.3552607196485433,"score_spread":0.3261101450461064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}