{"id":"W4392365481","doi":"10.2174/0115734064271581231219111952","title":"Biochemical and In Silico Studies on Triazole Derivatives as TyrosinaseInhibitors: Potential Treatment of Hyperpigmentation Related SkinDisorders","year":2024,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Higher Education Commission, Pakistan","keywords":"Tyrosinase; Kojic acid; Chemistry; Hyperpigmentation; Melanin; Enzyme; Docking (animal); IC50; Stereochemistry; Biochemistry; Active site; Melasma; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005302638,0.001043967,0.001576383,0.000708581,0.0003246218,0.0008487793,0.0006551904,0.0006068939,0.004093581],"category_scores_gemma":[0.0007691057,0.0003139832,0.00218502,0.0007538476,0.0001792157,0.0003351868,0.0002796209,0.0005529465,0.000638658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005919238,"about_ca_system_score_gemma":0.0008046068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004381084,"about_ca_topic_score_gemma":0.007351402,"domain_scores_codex":[0.9997817,0.00005175127,0.00001465721,0.00005234862,0.00005862359,0.00004095749],"domain_scores_gemma":[0.9997203,0.0001332132,0.00006294221,0.00001035704,0.00004945222,0.00002374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00341769,0.002666748,0.02975854,0.007811242,0.001841135,0.002470197,0.0001379465,0.6842989,0.2026616,0.002661035,0.004756403,0.05751846],"study_design_scores_gemma":[0.0004582182,0.00840594,0.0166161,0.0003197337,0.002682413,0.001475047,0.0002350909,0.8498011,0.09873238,0.00131405,0.01979825,0.0001617133],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9438491,0.02837543,0.01178107,0.0006459425,0.0001243934,0.0002601141,0.006255976,0.000526588,0.008181348],"genre_scores_gemma":[0.9685643,0.009571198,0.01367659,0.0001447565,0.0000281782,0.0001399217,0.00520917,0.00005363109,0.00261226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004381084,"threshold_uncertainty_score":0.01369441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182934870182438,"score_gpt":0.304447585426982,"score_spread":0.2926182367251576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}