{"id":"W4392365481","doi":"10.2174/0115734064271581231219111952","title":"Biochemical and In Silico Studies on Triazole Derivatives as TyrosinaseInhibitors: Potential Treatment of Hyperpigmentation Related SkinDisorders","year":2024,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"Higher Education Commission, Pakistan","keywords":"Tyrosinase; Kojic acid; Chemistry; Hyperpigmentation; Melanin; Enzyme; Docking (animal); IC50; Stereochemistry; Biochemistry; Active site; Melasma; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000891626,0.0001357617,0.0001587766,0.0000377984,0.00002484365,0.000008541339,0.00003594713,0.00010838,0.00001668046],"category_scores_gemma":[0.00007528751,0.0001125817,0.00004465006,0.00008949289,0.0001379089,0.000003741223,0.00001282391,0.00005274201,0.000001731612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004485364,"about_ca_system_score_gemma":0.00004573889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009863949,"about_ca_topic_score_gemma":8.634426e-7,"domain_scores_codex":[0.9991964,0.0000268656,0.0002494126,0.0002836715,0.0001339867,0.0001096375],"domain_scores_gemma":[0.9997597,0.0000281546,0.00005059622,0.00009746062,0.00002156603,0.00004249424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002439566,0.0001113106,0.0005785313,0.0001338299,0.00008559018,0.00002336668,0.0007610743,0.00002087872,0.9964359,0.000011973,0.0001918529,0.001401677],"study_design_scores_gemma":[0.001247792,0.0005089591,0.0005222341,0.0001415274,0.00003749729,0.00003031751,0.002465614,0.00006560573,0.9945759,0.0001182265,0.000187086,0.00009920132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902173,0.008820917,0.00001406089,0.0002161733,0.0001443304,0.0001228552,0.000006505564,0.000009501274,0.0004483942],"genre_scores_gemma":[0.9979379,0.001369497,0.00004058549,0.00002591921,0.0001314587,0.00002384962,0.0001742051,0.00001142142,0.0002851734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007720627,"threshold_uncertainty_score":0.459095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182934870182438,"score_gpt":0.304447585426982,"score_spread":0.2926182367251576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}