{"id":"W4392366375","doi":"10.1158/1557-3265.endo24-pr006","title":"Abstract PR006: ARID1A/B mutations retarget mSWI/SNF chromatin remodeler activity and define a spectrum of dedifferentiation in endometrial carcinoma","year":2024,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"ARID1A; Chromatin; Cancer research; Biology; Mutation; Chromatin remodeling; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007499605,0.0001876812,0.0001008911,0.0003378593,0.0001103372,0.0001719991,0.0001166174,0.0001761118,0.001239847],"category_scores_gemma":[0.0001286204,0.0001123316,0.0001286032,0.0001809877,0.0001522689,0.00007403196,0.0001661111,0.0001985352,0.0004611647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001013342,"about_ca_system_score_gemma":0.00006184338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003136027,"about_ca_topic_score_gemma":0.0004337491,"domain_scores_codex":[0.9999336,0.000006268183,0.00000799735,0.00001883631,0.00002202484,0.00001127781],"domain_scores_gemma":[0.9999175,0.00001211531,0.00003089492,0.000009389802,0.000009468737,0.00002071518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001369813,0.00001209309,0.007970056,0.0000214981,0.000006830859,0.0004768299,0.00002017938,0.00004064461,0.9895107,0.00005463002,0.00005273525,0.001696717],"study_design_scores_gemma":[0.00002853471,0.0003624152,0.2865239,0.00001191625,0.00003035552,0.01540215,0.0001803312,0.001734286,0.6902337,0.0002234451,0.005259741,0.00000916511],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965273,0.0003979723,0.001332731,0.00003266351,0.000005695983,0.00001744017,0.0007484767,0.00004096625,0.0008967495],"genre_scores_gemma":[0.9966751,0.0001950366,0.001382028,0.00003473958,0.000003063608,0.0000126705,0.0008415928,0.00001591005,0.0008398686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239847,"threshold_uncertainty_score":0.004147649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294138628076801,"score_gpt":0.4651211312747568,"score_spread":0.3357072684670767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}