{"id":"W4392367705","doi":"10.21203/rs.3.rs-3968879/v1","title":"Seeding Activity of Skin Misfolded Tau as a Biomarker for Tauopathies","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Weston Brain Institute; National Institutes of Health; Alzheimer's Association","keywords":"Tauopathy; Corticobasal degeneration; Progressive supranuclear palsy; Tau protein; Tau pathology; Biomarker; Pathology; Chemistry; Medicine; Disease; Biochemistry; Alzheimer's disease; Neurodegeneration","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007767485,0.0005445082,0.0003391309,0.001074034,0.0002537012,0.0009358677,0.0001982611,0.0006646509,0.003430905],"category_scores_gemma":[0.001301076,0.000190322,0.0003189204,0.0005255555,0.0003176281,0.0005053371,0.0003135408,0.0006046221,0.001262556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000241433,"about_ca_system_score_gemma":0.0001805756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005843686,"about_ca_topic_score_gemma":0.0003331085,"domain_scores_codex":[0.99964,0.0000878738,0.00001701493,0.0000915065,0.0001090366,0.0000545029],"domain_scores_gemma":[0.9993749,0.0002023951,0.00009487859,0.00008876771,0.0001266164,0.0001124137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009094755,0.000162937,0.01827283,0.000191531,0.00008814691,0.0003950587,0.0002830569,0.001003735,0.9481845,0.00226869,0.001612062,0.02662805],"study_design_scores_gemma":[0.00004611328,0.0007723648,0.05852954,0.00003984383,0.0001170984,0.001703203,0.0002684171,0.01504361,0.9137095,0.004524175,0.005209052,0.00003711997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682319,0.004039122,0.01696914,0.0003346592,0.0003121347,0.00006289381,0.001504436,0.0003856345,0.008160081],"genre_scores_gemma":[0.9797891,0.001316147,0.01128224,0.00009100468,0.00008286339,0.00003069366,0.001070267,0.0001006768,0.006237112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003430905,"threshold_uncertainty_score":0.01147753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1193298318190264,"score_gpt":0.4621821986331417,"score_spread":0.3428523668141153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}