{"id":"W4392368297","doi":"10.1371/journal.pgen.1011174","title":"Extreme restructuring of cis-regulatory regions controlling a deeply conserved plant stem cell regulator","year":2024,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of General Medical Sciences; Directorate for Biological Sciences; Howard Hughes Medical Institute; National Institutes of Health; National Science Foundation","keywords":"Biology; Arabidopsis; Regulatory sequence; Genetics; Regulator; Gene; Phenotype; Regulator gene; Conserved sequence; Arabidopsis thaliana; Regulation of gene expression; Mutant; Peptide sequence","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001352739,0.0002858053,0.0003296929,0.0001951197,0.0001218587,0.0003096257,0.0002523871,0.0003021464,0.000694104],"category_scores_gemma":[0.0001429225,0.0002076701,0.0003275034,0.0001096912,0.0003035783,0.0002221019,0.0003381075,0.0006993118,0.0003171324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002177241,"about_ca_system_score_gemma":0.0001414073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002639833,"about_ca_topic_score_gemma":0.000484326,"domain_scores_codex":[0.9998446,0.00001367271,0.00001044888,0.0000746019,0.00003573197,0.0000209365],"domain_scores_gemma":[0.9997937,0.00003589781,0.0000774664,0.00003564656,0.00001621341,0.00004104718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001006031,0.000001403658,0.0001673797,0.00000431716,0.00000160505,0.00001270734,0.000004776305,0.00003137189,0.9994435,0.00002199268,0.000001348248,0.0002996882],"study_design_scores_gemma":[0.000009182624,0.0002019594,0.0300453,0.000006399644,0.00003304968,0.000786973,0.00005883454,0.001768763,0.9650058,0.0002344692,0.001836855,0.00001245496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924549,0.000527373,0.006328842,0.00003709186,0.000005943692,0.000006765768,0.0001081852,0.0001221829,0.0004087203],"genre_scores_gemma":[0.9963419,0.0001448157,0.002654864,0.00003735006,0.000003890833,0.000007469741,0.0002720157,0.00003761939,0.0005000679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000694104,"threshold_uncertainty_score":0.002321959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05596105900502393,"score_gpt":0.218972410310341,"score_spread":0.163011351305317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}