{"id":"W4392374358","doi":"10.1101/2024.03.01.582837","title":"Nonlinear transcriptional responses to gradual modulation of transcription factor dosage","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Human Genome Research Institute; Science for Life Laboratory; Knut och Alice Wallenbergs Stiftelse; Canadian Institutes of Health Research; European Commission","keywords":"Transcription factor; Modulation (music); Transcription (linguistics); Biology; Genetics; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002367323,0.0004001635,0.0003304282,0.0002555912,0.00004586246,0.00006332633,0.0002763586,0.0004633242,0.0000202077],"category_scores_gemma":[0.00007607142,0.0004490705,0.0002415805,0.0002273475,0.00005065893,0.000005160945,0.0001657152,0.0003436107,0.00001724496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006102856,"about_ca_system_score_gemma":0.0002829758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002002923,"about_ca_topic_score_gemma":0.0000047157,"domain_scores_codex":[0.9980846,0.00006635299,0.0004721843,0.0007628094,0.0003060395,0.0003079953],"domain_scores_gemma":[0.9988237,0.00001157126,0.00009417955,0.0006512512,0.0002410068,0.0001782938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001280495,0.00006876153,0.0003226827,0.000428351,0.0001279098,0.000005408468,0.0000238038,0.00153018,0.9971719,0.00008193476,0.0001038388,0.000007124845],"study_design_scores_gemma":[0.0002746536,0.0001671102,0.05010269,0.0002196074,0.00008213036,3.313251e-8,0.000002547861,0.00114312,0.9427919,0.000003348972,0.004721282,0.0004916259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727415,0.002044578,0.0221255,0.0001726631,0.001112374,0.0004845779,0.00122507,0.00009012823,0.000003596468],"genre_scores_gemma":[0.9920106,0.0001927642,0.006899214,0.0000572703,0.0006252702,0.00008115872,0.000005806606,0.0001063115,0.00002159292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0543801,"threshold_uncertainty_score":0.9997961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490189584502743,"score_gpt":0.2660562135786634,"score_spread":0.251154317733636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}