{"id":"W4392374358","doi":"10.1101/2024.03.01.582837","title":"Nonlinear transcriptional responses to gradual modulation of transcription factor dosage","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Human Genome Research Institute; Science for Life Laboratory; Knut och Alice Wallenbergs Stiftelse; Canadian Institutes of Health Research; European Commission","keywords":"Transcription factor; Modulation (music); Transcription (linguistics); Biology; Genetics; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445812,0.0003618878,0.000280455,0.0001654184,0.0001167978,0.0004382084,0.0003095722,0.0003097739,0.001624611],"category_scores_gemma":[0.0003383963,0.0002173164,0.0001975714,0.0001203355,0.0005553995,0.0002158247,0.0005135715,0.0007317986,0.0003944585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004977073,"about_ca_system_score_gemma":0.0001455945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005615737,"about_ca_topic_score_gemma":0.0007706812,"domain_scores_codex":[0.999732,0.00002809742,0.00001971764,0.00009775253,0.00007736269,0.0000451182],"domain_scores_gemma":[0.9996613,0.0001221915,0.00008362125,0.00006399881,0.00003417739,0.00003459365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001765503,0.000005107043,0.0001563953,0.00001191462,0.000002273276,0.0000091168,0.000005980791,0.0002277662,0.9988781,0.00006210436,0.0000178436,0.0006058813],"study_design_scores_gemma":[0.000006527066,0.00005091487,0.002933433,0.00000269316,0.000005119729,0.00004131989,0.00001641864,0.003662706,0.9922524,0.0001180244,0.0009029051,0.000007525673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672771,0.0004135824,0.02931187,0.0001427442,0.00004121333,0.00003150473,0.0005277304,0.000475054,0.001779253],"genre_scores_gemma":[0.9924527,0.0001872775,0.004954812,0.0001003991,0.000007377436,0.00004678152,0.0002548908,0.00008778632,0.001908125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001624611,"threshold_uncertainty_score":0.005434871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490189584502743,"score_gpt":0.2660562135786634,"score_spread":0.251154317733636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}