{"id":"W4392376312","doi":"10.1158/1538-7445.brain23-ia004","title":"Abstract IA004: Targeting clonal heterogeneity in treatment-refractory Glioblastoma with novel and empiric immunotherapies","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Glioblastoma; Refractory (planetary science); Medicine; Immunotherapy; Cancer research; Oncology; Biology; Cancer; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002283967,0.0002696179,0.000329374,0.0005751363,0.0001902774,0.0005585965,0.000376828,0.0003584061,0.002767746],"category_scores_gemma":[0.0002101103,0.0001142833,0.0002231554,0.0002598889,0.0002091723,0.0002794714,0.0003095725,0.0007369393,0.0006693183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005093563,"about_ca_system_score_gemma":0.0005462228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004997196,"about_ca_topic_score_gemma":0.001111849,"domain_scores_codex":[0.9999304,0.00001326145,0.000005643135,0.000009682532,0.00002189455,0.00001916407],"domain_scores_gemma":[0.9999435,0.000008453665,0.00001175132,0.000006483758,0.00001308971,0.00001665308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001229978,0.0008783534,0.002297079,0.0006326193,0.00008890398,0.001000597,0.0001050445,0.002956961,0.4612685,0.004884132,0.03593408,0.4887238],"study_design_scores_gemma":[0.001465515,0.007898292,0.0248125,0.0004070413,0.0005054004,0.009843564,0.0002219612,0.01997456,0.5620105,0.007247976,0.365485,0.00012774],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.797792,0.09065681,0.03791218,0.01283468,0.003266467,0.0008864907,0.001096609,0.002012236,0.05354248],"genre_scores_gemma":[0.9149023,0.03925813,0.01473947,0.002059793,0.0005995053,0.000336245,0.001126223,0.0001363105,0.0268421],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.002767746,"threshold_uncertainty_score":0.009259045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.070886333453477,"score_gpt":0.4095909609713426,"score_spread":0.3387046275178656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}