{"id":"W4392376725","doi":"10.1177/13524585241234783","title":"Efficacy and safety results after >3.5 years of treatment with the Bruton’s tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study","year":2024,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Placebo; Expanded Disability Status Scale; Adverse effect; Population; Confidence interval; Tolerability; Multiple sclerosis; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004243416,0.001233723,0.003046575,0.0003900076,0.0005669738,0.001358397,0.0008233692,0.002035049,0.00256857],"category_scores_gemma":[0.002430052,0.0004134509,0.003233363,0.0003857794,0.000997619,0.001389784,0.0005633031,0.003392368,0.0008820724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009374075,"about_ca_system_score_gemma":0.0009178214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001346577,"about_ca_topic_score_gemma":0.001410933,"domain_scores_codex":[0.9983897,0.0006764064,0.0001170987,0.0002635574,0.0001385932,0.0004147035],"domain_scores_gemma":[0.9971089,0.000529178,0.0008588465,0.000253291,0.0002283798,0.001021517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9407629,0.01321999,0.006294009,0.0002604897,0.001539309,0.0001095695,0.0001334493,0.0006971661,0.004355256,0.00004171983,0.001191826,0.03139419],"study_design_scores_gemma":[0.3846541,0.5419232,0.0649648,0.00006443737,0.002425475,0.000203662,0.00008298348,0.0008731485,0.002750216,0.0001842663,0.001797079,0.00007667555],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933075,0.0036299,0.000232035,0.0003361543,0.0001384982,0.0003204821,0.0009240035,0.00004732014,0.001064036],"genre_scores_gemma":[0.9953258,0.0007771819,0.0001765352,0.0005352015,0.0001724382,0.0003510494,0.00141899,0.00001560731,0.001227186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004243416,"threshold_uncertainty_score":0.02244163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09712180060595654,"score_gpt":0.3453653086020778,"score_spread":0.2482435079961212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}