{"id":"W4392376725","doi":"10.1177/13524585241234783","title":"Efficacy and safety results after >3.5 years of treatment with the Bruton’s tyrosine kinase inhibitor evobrutinib in relapsing multiple sclerosis: Long-term follow-up of a Phase II randomised clinical trial with a cerebrospinal fluid sub-study","year":2024,"lang":"en","type":"article","venue":"Multiple Sclerosis Journal","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; NeuroRx Research (Canada)","funders":"","keywords":"Medicine; Internal medicine; Gastroenterology; Placebo; Expanded Disability Status Scale; Adverse effect; Population; Confidence interval; Tolerability; Multiple sclerosis; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004028048,0.0007599434,0.00212045,0.0006580559,0.0004919332,0.0002094995,0.0003402557,0.0002453161,0.00003859515],"category_scores_gemma":[0.002321394,0.0004546286,0.0006294426,0.001093346,0.001095407,0.0003638955,0.0003052076,0.001209781,0.000004227239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000551986,"about_ca_system_score_gemma":0.0007755065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002459793,"about_ca_topic_score_gemma":0.001385844,"domain_scores_codex":[0.9924365,0.001076744,0.002822961,0.001146386,0.001534526,0.0009828644],"domain_scores_gemma":[0.9943086,0.002857801,0.000776823,0.0009114866,0.0005472121,0.0005980852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7735488,0.00873706,0.09127332,0.0001766415,0.001727711,0.0002806256,0.006178135,0.00004259776,0.0591022,4.5078e-7,0.000182084,0.05875035],"study_design_scores_gemma":[0.4942243,0.03331491,0.4619525,0.005278936,0.0007375319,0.00005890895,0.0005419223,0.0007890417,0.002727399,2.800739e-7,0.00007782342,0.0002964395],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882221,0.003544573,0.00008681409,0.000677884,0.0005170707,0.006638641,0.0002298008,0.00006880608,0.00001426706],"genre_scores_gemma":[0.9937829,0.004210496,0.000607205,0.00003609033,0.0006788473,0.0004438146,0.00003185224,0.0001308742,0.0000778735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3706792,"threshold_uncertainty_score":0.9997905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09712180060595654,"score_gpt":0.3453653086020778,"score_spread":0.2482435079961212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}