{"id":"W4392377136","doi":"10.2147/jaa.s416292","title":"Impact of Exacerbation History on Dupilumab Efficacy in Children with Uncontrolled Moderate-to-Severe Asthma: LIBERTY ASTHMA VOYAGE Study","year":2024,"lang":"en","type":"article","venue":"Journal of Asthma and Allergy","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"Regeneron Pharmaceuticals; Sanofi","keywords":"Dupilumab; Medicine; Exhaled nitric oxide; Asthma; Exacerbation; Internal medicine; Eosinophil; Vital capacity; Population; Biomarker; Placebo; Physical therapy; Immunology; Diffusing capacity; Lung; Lung function; Spirometry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002644438,0.0003048178,0.0009697431,0.0001595287,0.0002443166,0.0005868456,0.0004336245,0.000362477,0.001278664],"category_scores_gemma":[0.002094658,0.0001985375,0.001416219,0.0001943884,0.0002947749,0.0003451395,0.0005343242,0.0008634816,0.0001052542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000677528,"about_ca_system_score_gemma":0.0007872593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00128103,"about_ca_topic_score_gemma":0.004188952,"domain_scores_codex":[0.9984139,0.0007218256,0.0001074396,0.0002754861,0.0003063195,0.0001749717],"domain_scores_gemma":[0.9983444,0.0005949853,0.0005937954,0.0001210617,0.00007373223,0.0002719652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09126017,0.0006912964,0.877281,0.0003643868,0.002108745,0.0002855055,0.0002080695,0.0005065255,0.002963165,0.0001283316,0.001138675,0.02306413],"study_design_scores_gemma":[0.006138821,0.01267298,0.9769645,0.00005800103,0.0009037395,0.0005156439,0.00007832764,0.0007426631,0.0006794844,0.00003324188,0.001198074,0.00001446386],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981928,0.0008666718,0.00005752768,0.00007116576,0.000008859683,0.00005700889,0.0004030074,0.000003395773,0.0003396388],"genre_scores_gemma":[0.9988797,0.0001169282,0.0001209426,0.00007950657,0.00001510398,0.00005402671,0.0006082591,0.000002670605,0.0001227754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002644438,"threshold_uncertainty_score":0.01398528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009170568336034668,"score_gpt":0.261858357576582,"score_spread":0.2526877892405474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}