{"id":"W4392377470","doi":"10.3390/biomedicines12030571","title":"Potential Cytoprotective and Anti-Apoptotic Effect of Metamizole Alone and in Combination with Cytostatic Drugs Observed In Vitro in Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metamizole; Pharmacology; Propidium iodide; Osteosarcoma; Apoptosis; Doxorubicin; Medicine; Cisplatin; Etoposide; Viability assay; MTT assay; Chemotherapy; Analgesic; Cancer research; Chemistry; Internal medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001457773,0.0001465526,0.0002717452,0.0002037956,0.00001943635,0.00001292275,0.00003079243,0.00007042027,8.258448e-7],"category_scores_gemma":[0.0000112701,0.0001061456,0.00001363337,0.0002134668,0.0001328806,0.000008616452,0.00004047616,0.00005706602,8.110372e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008042025,"about_ca_system_score_gemma":0.00001738077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001354434,"about_ca_topic_score_gemma":0.0007326541,"domain_scores_codex":[0.9992836,0.00006606181,0.0001750137,0.0002697074,0.00007650924,0.0001290983],"domain_scores_gemma":[0.999806,0.00002516736,0.00003969423,0.0000774252,0.00001811162,0.00003352948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236,0.0001634198,0.07471819,0.000448221,0.00004982367,0.00005907677,0.0002796657,0.000003570841,0.9212522,0.000002601007,0.000005057243,0.002694556],"study_design_scores_gemma":[0.01156086,0.002228191,0.2913559,0.0002861059,0.000121477,0.00002791466,0.0003465523,0.0003936486,0.6934064,0.00007687058,0.00001230618,0.0001837735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923222,0.007039269,0.00001208121,0.0001497916,0.00002426255,0.0004211481,0.00001320646,0.000004671083,0.0000133856],"genre_scores_gemma":[0.999504,0.000208254,0.00007822608,0.00001537023,0.0000146004,0.00003192834,0.0001027957,0.00001282758,0.0000320529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2278458,"threshold_uncertainty_score":0.432849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004300803862615842,"score_gpt":0.2268606750065621,"score_spread":0.2225598711439463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}