{"id":"W4392377470","doi":"10.3390/biomedicines12030571","title":"Potential Cytoprotective and Anti-Apoptotic Effect of Metamizole Alone and in Combination with Cytostatic Drugs Observed In Vitro in Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Blood disorders and treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metamizole; Pharmacology; Propidium iodide; Osteosarcoma; Apoptosis; Doxorubicin; Medicine; Cisplatin; Etoposide; Viability assay; MTT assay; Chemotherapy; Analgesic; Cancer research; Chemistry; Internal medicine; Programmed cell death; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115373,0.000209201,0.0002929232,0.0002950817,0.00008355521,0.0001202585,0.0001045028,0.0001849178,0.0006209541],"category_scores_gemma":[0.00008590926,0.00006353061,0.0001632139,0.0001933916,0.000101474,0.0001114015,0.0000821335,0.0002081822,0.0001076823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001037945,"about_ca_system_score_gemma":0.0001238674,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004292034,"about_ca_topic_score_gemma":0.0009064798,"domain_scores_codex":[0.9999217,0.00002033898,0.000009817877,0.0000144239,0.00001980208,0.0000140108],"domain_scores_gemma":[0.9999416,0.00001686896,0.00001449336,0.000005404023,0.00001110981,0.00001053959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004406121,0.00008148329,0.0005073879,0.0001129903,0.0000115107,0.00007484718,0.00002437262,0.00009981277,0.9954737,0.00004488932,0.00003648411,0.003091908],"study_design_scores_gemma":[0.00002923862,0.001713833,0.00503457,0.000008571008,0.00004198633,0.0001814853,0.0000402354,0.0002953207,0.9906225,0.00002061418,0.002007754,0.000003809394],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932454,0.004370583,0.000885225,0.00006192577,0.00002333565,0.00002986344,0.0002647341,0.00003034596,0.001088612],"genre_scores_gemma":[0.9954827,0.00196843,0.001256924,0.00002609343,0.000009949372,0.00002293742,0.0003104276,0.000004218973,0.0009182704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006209541,"threshold_uncertainty_score":0.002077341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004300803862615842,"score_gpt":0.2268606750065621,"score_spread":0.2225598711439463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}