{"id":"W4392401869","doi":"10.3389/fnmol.2024.1328578","title":"Invertebrate genetic models of amyotrophic lateral sclerosis","year":2024,"lang":"en","type":"article","venue":"Frontiers in Molecular Neuroscience","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Jiangxi Provincial Department of Science and Technology; Health and Family Planning Commission of Jiangxi Province; National Natural Science Foundation of China; Faculté de Médecine, Université Laval; Université Laval","keywords":"Amyotrophic lateral sclerosis; Neuroscience; Disease; Pathogenesis; Biology; Spinal cord; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002017921,0.0001870145,0.0003317936,0.0004847312,0.00004185682,0.0000734547,0.000357357,0.0000938915,0.00002069364],"category_scores_gemma":[0.00006246527,0.0001615703,0.0001040012,0.001299011,0.0004535241,0.0002364531,0.0001580312,0.0003720145,0.00001091636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001078522,"about_ca_system_score_gemma":0.0001951128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008734423,"about_ca_topic_score_gemma":0.000001426239,"domain_scores_codex":[0.9976458,0.0001063686,0.0003663726,0.0006297458,0.0007349838,0.000516705],"domain_scores_gemma":[0.9992728,0.00001137678,0.00003739677,0.0004315818,0.00004911543,0.0001976943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00005884326,0.0000855675,0.009489248,0.0001919393,0.00001191181,0.000880039,0.0001376076,0.005716373,0.9763452,0.0003703822,0.001352222,0.005360624],"study_design_scores_gemma":[0.000630164,0.0004030001,0.08950086,0.0004637565,0.00003423548,0.00006695028,0.0000107061,0.8824553,0.02218573,0.003633117,0.000366065,0.0002500852],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9409753,0.001825444,0.05473549,0.0007546545,0.0008464173,0.0004185258,0.00001078169,0.0000779273,0.000355443],"genre_scores_gemma":[0.9887902,0.0006286145,0.009553839,0.000701824,0.00002447479,0.00002482375,0.000003184718,0.00003969283,0.0002333697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9541595,"threshold_uncertainty_score":0.6588647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172702496097564,"score_gpt":0.2662939845144735,"score_spread":0.2345669595534979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}