{"id":"W4392450437","doi":"10.1038/s41525-024-00395-y","title":"Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease","year":2024,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of British Columbia; University Health Network","funders":"Medical Research and Materiel Command; National Cancer Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Cancer Institute NSW; Ovarian Cancer Research Fund; Cancer Australia; National Institute for Health and Care Research; National Health and Medical Research Council; Norges Forskningsråd; Moffitt Cancer Center; Minnesota Ovarian Cancer Alliance; Wellcome Trust; Cancer Research UK; National Center for Research Resources; BC Cancer Foundation; Fred C. and Katherine B. Andersen Foundation; Helse Vest; Ovarian Cancer Australia; National Center for Advancing Translational Sciences; Medical Research Council; Cancer Research Society; Mayo Foundation for Medical Education and Research; Ministerio de Economía y Competitividad; University of Pittsburgh; National Institutes of Health; European Commission; U.S. Department of Defense","keywords":"Debulking; Ovarian cancer; Disease; Medicine; Genome-wide association study; Oncology; Gene; Candidate gene; Genetic association; Internal medicine; Biology; Bioinformatics; Cancer; Genetics; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005780397,0.000247552,0.0007160131,0.0003532601,0.000101706,0.00002912377,0.0000804267,0.00008769784,0.0003535325],"category_scores_gemma":[0.0005632758,0.000195102,0.0002115744,0.0002711073,0.00005104476,0.00007927856,0.00004106374,0.0001083373,0.000009686179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001552813,"about_ca_system_score_gemma":0.001057925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008442322,"about_ca_topic_score_gemma":0.0001992196,"domain_scores_codex":[0.9978672,0.00006192583,0.0007146589,0.0004925908,0.0004943446,0.0003692344],"domain_scores_gemma":[0.9973474,0.001595686,0.0003023861,0.0002880697,0.0002135912,0.0002528704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000369662,0.0001677931,0.9697761,0.00184318,0.001739324,0.00006399061,0.0003626247,0.00006078522,0.004387092,0.00002434756,0.01312127,0.008083837],"study_design_scores_gemma":[0.002442101,0.0001822562,0.9839251,0.001531507,0.00281317,0.000001233889,0.0000442713,0.00007262616,0.001035388,0.0001815658,0.007595471,0.0001752829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578765,0.03116931,0.0002607462,0.007895793,0.001317958,0.0008606541,0.0002630441,0.00006713547,0.0002888348],"genre_scores_gemma":[0.9893882,0.006039672,0.0001935832,0.001014741,0.001224709,0.0002086769,0.0009391355,0.0000625783,0.0009287263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03151166,"threshold_uncertainty_score":0.7956029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311196093886641,"score_gpt":0.339936937273058,"score_spread":0.2968249763341916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}