{"id":"W4392451032","doi":"10.1126/scisignal.adh4475","title":"eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer","year":2024,"lang":"en","type":"article","venue":"Science Signaling","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; National Cancer Institute; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas","keywords":"PTEN; Cancer research; Ubiquitin ligase; Mitosis; Biology; Cell cycle; Kinase; Cell growth; Skp1; Ubiquitin; Cell biology; Signal transduction; Chemistry; Cancer; PI3K/AKT/mTOR pathway; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001043483,0.000286395,0.0001753785,0.0003098652,0.0001613738,0.0002010139,0.0001168515,0.0001355178,0.001572574],"category_scores_gemma":[0.0000660364,0.0001327267,0.0002765009,0.0001598255,0.0001081298,0.00009390184,0.0001569339,0.0003384695,0.0004517135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002582867,"about_ca_system_score_gemma":0.0001880146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007535306,"about_ca_topic_score_gemma":0.001041963,"domain_scores_codex":[0.9999198,0.000007657307,0.000006926217,0.00001716852,0.00002188843,0.00002651535],"domain_scores_gemma":[0.999967,0.000002528033,0.000009536587,0.000003537945,0.000003965081,0.00001346657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002341497,0.00004572423,0.000557127,0.0000530384,0.00001537762,0.00009404164,0.000006896641,0.0000701287,0.9963252,0.00009251825,0.0001971151,0.002308833],"study_design_scores_gemma":[0.00003686553,0.0002069535,0.01288677,0.000005983533,0.00002693223,0.0007830927,0.00001866338,0.001365691,0.9772221,0.00005665211,0.007385884,0.00000447975],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885987,0.005384255,0.002174034,0.0001633026,0.0000631942,0.00002463803,0.0006047029,0.0001953365,0.002791702],"genre_scores_gemma":[0.9934063,0.001151252,0.000445472,0.00003533812,0.0000072618,0.00002915941,0.0007894947,0.00001182866,0.004123948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572574,"threshold_uncertainty_score":0.005260825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01449119851008562,"score_gpt":0.2778713927311576,"score_spread":0.263380194221072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}