{"id":"W4392454080","doi":"10.21203/rs.3.rs-3971970/v1","title":"Analysis of expression status and relationship between senescence- related genes and pancreatic function-related genes in human islets of various ages","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"University of Alberta; Alberta Health Services","keywords":"Gene; Senescence; Pancreatic islets; Biology; Expression (computer science); Function (biology); Islet; Gene expression; Genetics; Cell biology; Endocrinology; Diabetes mellitus; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003357116,0.000162812,0.0001845111,0.0005581051,0.0001271265,0.000324132,0.00007489506,0.0001467602,0.001157537],"category_scores_gemma":[0.0002970528,0.0001227481,0.0001895697,0.0005381949,0.0001532141,0.0001846217,0.0001574427,0.0002890553,0.0002285213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008557387,"about_ca_system_score_gemma":0.00008217682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001913948,"about_ca_topic_score_gemma":0.0001820183,"domain_scores_codex":[0.9998466,0.00001906161,0.00001689021,0.00006665228,0.0000297469,0.00002098964],"domain_scores_gemma":[0.9996567,0.00007751017,0.0001259852,0.00002623039,0.00007117511,0.00004244332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001034422,0.00006872837,0.1284992,0.0001642551,0.00008583872,0.0001841958,0.0003094457,0.0001498898,0.8585315,0.00006477556,0.0001035553,0.01080415],"study_design_scores_gemma":[0.00002109513,0.0007158964,0.8119868,0.00002323593,0.0001524557,0.0008033169,0.0003995846,0.0007535278,0.1824407,0.00016126,0.002523221,0.00001897317],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950193,0.002080467,0.001690945,0.00001969404,0.00001471999,0.00001344679,0.0006603356,0.0000205533,0.0004804693],"genre_scores_gemma":[0.9942298,0.001287698,0.002269554,0.00005091752,0.00002303347,0.00006482175,0.0009162811,0.00001248334,0.00114544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157537,"threshold_uncertainty_score":0.003872395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07165522325575686,"score_gpt":0.3854492098601104,"score_spread":0.3137939866043535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}