{"id":"W4392465714","doi":"10.1101/2024.03.01.582976","title":"The Molecular Determinants of a Universal Prion Acceptor","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Hamster; Biology; Mesocricetus; Virology; Prion protein; In vitro; Viral replication; Fungal prion; Cell biology; Genetics; Phenotype; Molecular biology; Virus; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002697889,0.000281663,0.0002175905,0.0001375394,0.000164409,0.0003635457,0.0003084133,0.0003072529,0.0006825507],"category_scores_gemma":[0.0003280293,0.000151231,0.0002851798,0.00009618291,0.000346745,0.0003267989,0.000358607,0.0005076808,0.0004081925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000211472,"about_ca_system_score_gemma":0.000181069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000227588,"about_ca_topic_score_gemma":0.0002110693,"domain_scores_codex":[0.9998704,0.00003214306,0.00001410615,0.00002530572,0.00003273597,0.00002524574],"domain_scores_gemma":[0.999729,0.00006473067,0.00007628017,0.00002911539,0.00002889223,0.00007209599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006331466,0.00001865534,0.0007368164,0.00002016421,0.000006434526,0.0001260455,0.00001236009,0.0001687797,0.9978577,0.0002965328,0.000010511,0.0006827035],"study_design_scores_gemma":[0.00002428524,0.0005993291,0.0132564,0.00001947505,0.00003099327,0.0010995,0.00006447698,0.003594939,0.9795235,0.0003985138,0.001375292,0.00001324354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965951,0.0002713898,0.002454901,0.00001925165,0.000004738635,0.000009657519,0.00003555631,0.00001131139,0.0005981064],"genre_scores_gemma":[0.9981586,0.00007278856,0.001457328,0.00001557473,0.000002624628,0.0000055627,0.00008682942,0.00000614094,0.0001945142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006825507,"threshold_uncertainty_score":0.002283394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007297143953595569,"score_gpt":0.2296065859355278,"score_spread":0.2223094419819322,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}