{"id":"W4392470492","doi":"10.3390/toxins16030136","title":"Unveiling the Broad Substrate Specificity of Deoxynivalenol Oxidation Enzyme DepA and Its Role in Detoxifying Trichothecene Mycotoxins","year":2024,"lang":"en","type":"article","venue":"Toxins","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada; Grain Farmers of Ontario","keywords":"Chemistry; Enzyme kinetics; Zearalenone; Docking (animal); Stereochemistry; Enzyme; Mycotoxin; Active site; Biochemistry; Food science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001331461,0.0003393018,0.0002488581,0.000124748,0.0001028525,0.0003406823,0.0001336065,0.0002047436,0.00051475],"category_scores_gemma":[0.0001639428,0.00008828145,0.0003107521,0.0001595514,0.0001472507,0.0003007628,0.0002338572,0.0003522,0.0001670008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622323,"about_ca_system_score_gemma":0.0002997944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000791395,"about_ca_topic_score_gemma":0.001086397,"domain_scores_codex":[0.9999334,0.000009465077,0.000005154423,0.00001879317,0.00002214938,0.00001106995],"domain_scores_gemma":[0.9999514,0.00001332133,0.00001322375,0.000005199166,0.0000103172,0.000006484155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008239376,0.00003697584,0.001625408,0.00007494878,0.00001136728,0.00005990599,0.0000198436,0.001474339,0.9891572,0.0003613398,0.00003124998,0.007064964],"study_design_scores_gemma":[0.000007960302,0.0002544923,0.007499002,0.000009668097,0.00002378276,0.0002985501,0.00008152717,0.01839786,0.9692754,0.0003796582,0.003761418,0.00001076014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988537,0.001419777,0.008752678,0.0001454118,0.00001102565,0.00001204697,0.0001777862,0.00004282203,0.0009013215],"genre_scores_gemma":[0.9954047,0.000671702,0.003179005,0.00001315217,0.000002619272,0.000004928274,0.0001750226,0.000005853565,0.0005430455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000791395,"threshold_uncertainty_score":0.00190264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326383616813877,"score_gpt":0.2364051218812961,"score_spread":0.2231412857131574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}