{"id":"W4392470492","doi":"10.3390/toxins16030136","title":"Unveiling the Broad Substrate Specificity of Deoxynivalenol Oxidation Enzyme DepA and Its Role in Detoxifying Trichothecene Mycotoxins","year":2024,"lang":"en","type":"article","venue":"Toxins","topic":"Microbial metabolism and enzyme function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada","funders":"Agriculture and Agri-Food Canada; Grain Farmers of Ontario","keywords":"Chemistry; Enzyme kinetics; Zearalenone; Docking (animal); Stereochemistry; Enzyme; Mycotoxin; Active site; Biochemistry; Food science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002784826,0.0001243234,0.0001262888,0.00007929673,0.00005339334,0.00002900597,0.0001057773,0.0001171604,0.00004446501],"category_scores_gemma":[0.00004294312,0.00009971186,0.00005102291,0.0002182514,0.0000320645,0.00001262135,0.00004386494,0.0001196752,0.00001493338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001227934,"about_ca_system_score_gemma":0.00004469779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000408743,"about_ca_topic_score_gemma":0.0001784121,"domain_scores_codex":[0.9991617,0.00006704842,0.0002326566,0.0002745208,0.00008242228,0.0001817165],"domain_scores_gemma":[0.9996892,0.00002235595,0.00004874382,0.0001716793,0.00003103744,0.00003703595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004877477,0.00002678658,0.0002081489,0.00005252038,0.0000173824,0.000002000711,0.0001576378,0.0001293309,0.9953871,0.0003204666,0.0001761296,0.003473728],"study_design_scores_gemma":[0.000239137,0.00004959253,0.004095379,0.00004302537,0.00001858166,0.00001415619,0.0001200134,0.0008520046,0.9782591,0.00008329861,0.01610855,0.0001170954],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983429,0.01478727,0.000677234,0.00006475697,0.000210773,0.0001879133,0.0000322654,0.00001696647,0.0005938081],"genre_scores_gemma":[0.9969173,0.002270665,0.0001034,0.00004684967,0.0002398467,0.000008991068,0.00003434243,0.00001886502,0.0003597157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01712793,"threshold_uncertainty_score":0.4066132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01326383616813877,"score_gpt":0.2364051218812961,"score_spread":0.2231412857131574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}