{"id":"W4392482408","doi":"10.1016/j.ygyno.2024.01.045","title":"Phase 1b study of mirvetuximab soravtansine, a folate receptor alpha (FRα)–targeting antibody-drug conjugate, in combination with carboplatin and bevacizumab in patients with platinum-sensitive ovarian cancer","year":2024,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; McGill University Health Centre","funders":"ImmunoGen","keywords":"Medicine; Bevacizumab; Carboplatin; Conjugate; Ovarian cancer; Antibody-drug conjugate; Folate receptor; Antibody; Oncology; Drug; Pharmacology; Internal medicine; Cancer research; Cancer; Monoclonal antibody; Chemotherapy; Immunology; Cisplatin; Cancer cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004068795,0.0003074231,0.000909577,0.0003633804,0.00005813205,0.00002171333,0.00005513215,0.0001698891,0.00009242148],"category_scores_gemma":[0.00009245308,0.000219586,0.00003157431,0.0006283348,0.0001290845,0.0001386874,0.0000480638,0.0003699882,0.000003179364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008861473,"about_ca_system_score_gemma":0.0004741586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003974,"about_ca_topic_score_gemma":0.007663824,"domain_scores_codex":[0.9978576,0.0002745643,0.000585872,0.0006549715,0.0002470145,0.00038],"domain_scores_gemma":[0.9987253,0.0005635756,0.0002377743,0.0001749112,0.0002019701,0.00009646691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006048357,0.02790834,0.9096524,0.0002213932,0.0006417694,0.001582923,0.008938928,0.00008904951,0.0003692383,0.000203382,0.0001783859,0.04416591],"study_design_scores_gemma":[0.112445,0.04414733,0.8375854,0.0005834542,0.0004046448,0.00001572701,0.002599346,0.001268546,0.0003443045,0.00005856119,0.000234453,0.0003132303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950705,0.0004607626,0.00001108376,0.0009706086,0.0002505612,0.002663732,0.00007749681,0.00004626289,0.0004490146],"genre_scores_gemma":[0.9984919,0.00009797952,0.0007334361,0.0001309403,0.00002906236,0.000278304,0.0001687824,0.00003492035,0.00003469251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1063967,"threshold_uncertainty_score":0.8954459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111091942545518,"score_gpt":0.3107141787606278,"score_spread":0.299604984506076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}