{"id":"W4392506974","doi":"10.1016/bs.acc.2024.02.004","title":"Advances in familial hypercholesterolemia","year":2024,"lang":"en","type":"article","venue":"Advances in clinical chemistry","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Clinical Research Institute","funders":"","keywords":"Familial hypercholesterolemia; Guideline; Medicine; Risk stratification; Atherosclerotic cardiovascular disease; Disease; Intensive care medicine; Clinical trial; Precision medicine; Internal medicine; Pathology; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001043871,0.0001666185,0.0005279323,0.00003819957,0.00001677604,0.00001588215,0.0001323755,0.0002389765,0.00005826484],"category_scores_gemma":[0.0004753538,0.0001408638,0.0002753679,0.0003107422,0.0001473086,0.0002937403,0.00005524276,0.0009920202,0.00003830745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000118134,"about_ca_system_score_gemma":0.0001925199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001357419,"about_ca_topic_score_gemma":0.00003801417,"domain_scores_codex":[0.9979261,0.00005150307,0.0007829784,0.0005712993,0.0003384271,0.0003296477],"domain_scores_gemma":[0.9990361,0.0002752272,0.00004035787,0.0004602095,0.00002696646,0.0001611014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001958506,0.0002015767,0.09342413,0.002044065,0.00001767646,0.0006200437,0.00003885724,0.0000632189,0.0004345153,0.00004664551,0.00004323372,0.9028702],"study_design_scores_gemma":[0.004912298,0.0002931319,0.04374225,0.003705507,0.0000781589,0.0002320647,0.0003119416,0.0005652978,0.00376583,0.003062027,0.9388072,0.0005242237],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8162581,0.1517267,0.0001239341,0.0005145622,0.0006851038,0.0002659491,0.000008059132,0.0001040646,0.03031354],"genre_scores_gemma":[0.9296628,0.06776248,0.0005600169,0.0004153833,0.001139974,0.00005001036,0.00001649724,0.00002525935,0.0003676196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.938764,"threshold_uncertainty_score":0.5744258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02398084689320888,"score_gpt":0.3991943561336079,"score_spread":0.375213509240399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}