{"id":"W4392508187","doi":"10.3390/epigenomes8010010","title":"Exploring Transcriptional Regulation of Beta Cell SASP by Brd4-Associated Proteins and Cell Cycle Control Protein p21","year":2024,"lang":"en","type":"article","venue":"Epigenomes","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Canadian Institutes of Health Research; Human Islet Research Network; National Institute of Diabetes and Digestive and Kidney Diseases; University of Manitoba; University of Pennsylvania","keywords":"Bromodomain; Biology; Cell biology; Gene knockdown; Senescence; Beta cell; BRD4; Cell cycle; Chromatin; Cell culture; Cell; Cancer research; Gene; Epigenetics; Islet; Insulin; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861816,0.0001312316,0.0001382491,0.00005367465,0.0000654977,0.00003402427,0.0000751352,0.00009611916,0.00004513974],"category_scores_gemma":[0.00001544337,0.0001285995,0.00006962178,0.00009212681,0.00005470653,0.00002087441,0.00001907021,0.00007663613,0.000006386202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001961343,"about_ca_system_score_gemma":0.00005810165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003352793,"about_ca_topic_score_gemma":0.000005164397,"domain_scores_codex":[0.9991034,0.00006413741,0.0002417941,0.0002800589,0.000145825,0.0001647694],"domain_scores_gemma":[0.99968,0.000008418149,0.00006999103,0.0001331196,0.00005086189,0.00005756124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002776137,0.00006268505,0.00017631,0.00009668331,0.00002603168,5.360234e-7,0.0001209165,0.00001591127,0.997894,0.0001492845,0.0004289845,0.001000849],"study_design_scores_gemma":[0.0005813613,0.0001984504,0.002108387,0.00003847193,0.00001742689,5.685731e-7,0.00004826959,0.0001227197,0.972745,0.0001704554,0.02381362,0.000155266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874185,0.00798145,0.002416214,0.0003767157,0.0001199475,0.0006375686,0.0001380466,0.00003229236,0.0008792512],"genre_scores_gemma":[0.9966931,0.0001453122,0.0002507418,0.00003858841,0.0001212832,0.0001388907,0.0002231929,0.00002365385,0.0023652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02514905,"threshold_uncertainty_score":0.5244136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01471400800798344,"score_gpt":0.2029517817955723,"score_spread":0.1882377737875888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}