{"id":"W4392508897","doi":"10.1038/s41594-024-01245-2","title":"Guiding the HBO1 complex function through the JADE subunit","year":2024,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; Japan Society for the Promotion of Science; Canadian Institutes of Health Research; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Histone acetyltransferase; Histone; Chromatin; Protein subunit; Biology; Cell biology; Epigenetics; Nucleosome; JADE (particle detector); Chromatin remodeling; DNA methylation; Histone H3; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716288,0.000238095,0.0001312992,0.00003449724,0.0002999562,0.00009109949,0.0004457466,0.0004959477,0.0001073456],"category_scores_gemma":[0.0001331053,0.000124348,0.0001868124,0.0002477166,0.0002695916,0.000008219379,0.000182377,0.0004934959,0.00002098568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002024017,"about_ca_system_score_gemma":0.00005775565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002770542,"about_ca_topic_score_gemma":0.00001542345,"domain_scores_codex":[0.9986455,0.000237519,0.0002186911,0.0004510007,0.0001366741,0.0003106551],"domain_scores_gemma":[0.9993014,0.00002618318,0.00006217149,0.0004856231,0.00008694781,0.00003772396],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003666086,0.000002245001,0.00003604844,0.000008853702,0.0001221536,0.000004317274,0.00004042012,0.0000192159,0.9192068,0.06153629,0.014405,0.004582025],"study_design_scores_gemma":[0.0001831873,0.0001793237,0.000738362,0.00001095947,0.0000493232,0.0001076312,0.00008548339,0.0002289313,0.2687667,0.01149852,0.7179254,0.0002262222],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8549449,0.0570251,0.03322674,0.03827911,0.006521269,0.001394877,0.000134834,0.000241926,0.008231194],"genre_scores_gemma":[0.9913293,0.00008210976,0.0003130565,0.006492402,0.0007810634,0.00002679206,0.0005451091,0.00002840565,0.0004017456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7035204,"threshold_uncertainty_score":0.5070763,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396041869711492,"score_gpt":0.3122772542253095,"score_spread":0.2983168355281946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}