{"id":"W4392511075","doi":"10.1080/22221751.2024.2327371","title":"Effective and targeted latency reversal in CD4 <sup>+</sup> T cells from individuals on long term combined antiretroviral therapy initiated during chronic HIV-1 infection","year":2024,"lang":"en","type":"article","venue":"Emerging Microbes & Infections","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Maple Leaf Medical Clinic; University of Toronto; Western University","funders":"NHLBI Division of Intramural Research; Canadian Institutes of Health Research; Canada Research Chairs; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Gilead Sciences; National Institutes of Health; amfAR, The Foundation for AIDS Research","keywords":"Cart; Antiretroviral therapy; Human immunodeficiency virus (HIV); Medicine; Immunology; Virology; Latency (audio); Virus latency; Population; Viral replication; Virus; Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002622076,0.000194014,0.0003124216,0.0001047068,0.0001776252,0.0004415399,0.0002062295,0.0003538341,0.001166873],"category_scores_gemma":[0.0002715994,0.000137125,0.0001269126,0.00006671264,0.0002148011,0.0001991844,0.0002372583,0.0006654543,0.0002095903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001300301,"about_ca_system_score_gemma":0.0002748011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004792525,"about_ca_topic_score_gemma":0.0008786467,"domain_scores_codex":[0.9998485,0.00003164494,0.000009565722,0.00002159838,0.00002294816,0.00006567472],"domain_scores_gemma":[0.9999208,0.00002381752,0.00001132923,0.00001020486,0.000009263046,0.00002447627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.00282263,0.001441488,0.004576774,0.0001385152,0.00002947444,0.0002116327,0.0001925281,0.0006113659,0.9378365,0.0001559422,0.0004224788,0.05156068],"study_design_scores_gemma":[0.001580174,0.06770787,0.05920996,0.00007455618,0.0001747056,0.002032713,0.0004616102,0.003805908,0.856191,0.00033397,0.008399846,0.00002765652],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984494,0.0004829993,0.0003541964,0.00004684638,0.00001528446,0.00006082386,0.00004684951,0.00002047834,0.0005230689],"genre_scores_gemma":[0.9978515,0.0002411455,0.000620335,0.0001009207,0.00002268772,0.00004751101,0.0001146875,0.000005332905,0.0009958474],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001166873,"threshold_uncertainty_score":0.003903627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009510113041258525,"score_gpt":0.259580378304069,"score_spread":0.2500702652628105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}