{"id":"W4392512541","doi":"10.2196/54086","title":"Carboplatin in Patients With Metastatic Castration-Resistant Prostate Cancer Harboring Somatic or Germline Homologous Recombination Repair Gene Mutations: Phase II Single-Arm Trial","year":2024,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Prostate cancer; Carboplatin; Medicine; Homologous recombination; Germline; Somatic cell; Germline mutation; Oncology; Gene; Internal medicine; Mutation; Genetics; Cancer; Biology; Cisplatin; Chemotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001047027,0.001328337,0.002103951,0.0003931228,0.0002995655,0.001140036,0.0008652074,0.001282473,0.003259441],"category_scores_gemma":[0.0007204809,0.0004926985,0.001644203,0.0005412829,0.000592512,0.0006480446,0.0002831025,0.002253781,0.0005450836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001046139,"about_ca_system_score_gemma":0.001293757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001444842,"about_ca_topic_score_gemma":0.003272696,"domain_scores_codex":[0.9996982,0.0001282608,0.00001706124,0.00005970961,0.0000363527,0.00006054172],"domain_scores_gemma":[0.9995571,0.00006975051,0.0001175776,0.00004309566,0.0000349202,0.0001775068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8444331,0.01946134,0.004105833,0.002733447,0.002953546,0.0001870753,0.0001885953,0.00335409,0.01477675,0.0002624916,0.003460371,0.1040835],"study_design_scores_gemma":[0.8652067,0.1214176,0.007793765,0.000103056,0.0006920834,0.0001974972,0.0000314262,0.001024931,0.001148555,0.0001883419,0.002170689,0.00002540912],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9768844,0.01444138,0.0007105313,0.0007019504,0.0002861865,0.003312075,0.001255879,0.0001840869,0.002223463],"genre_scores_gemma":[0.9842626,0.007166643,0.001071857,0.00122926,0.0002255618,0.001938454,0.001634475,0.00002636474,0.002444852],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.003259441,"threshold_uncertainty_score":0.01090395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1875752080969176,"score_gpt":0.5174424609602524,"score_spread":0.3298672528633347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}