{"id":"W4392514676","doi":"10.1038/s42003-024-05924-0","title":"ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Glycomics Network; National Institute of Diabetes and Digestive and Kidney Diseases; Biotechnology and Biological Sciences Research Council; Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Cancer Research UK; Academy of Medical Sciences; Newcastle University; Mark Foundation For Cancer Research; Prostate Cancer UK; Movember Foundation; Prostate Cancer Foundation; Alberta Innovates; JGW Patterson Foundation; Directorate for Biological Sciences","keywords":"Prostate cancer; Enzalutamide; Immune system; Cancer research; Immune checkpoint; Prostate; Cancer; Blockade; Immunology; Androgen receptor; Biology; Immunotherapy; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008696056,0.0001594556,0.00009396132,0.00009592406,0.00007981878,0.0002595507,0.00008395272,0.000134168,0.0005983194],"category_scores_gemma":[0.00006569559,0.00005429351,0.00008440634,0.00008908381,0.0001698654,0.0001260894,0.0001070763,0.0003285107,0.0001403686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002644828,"about_ca_system_score_gemma":0.0002182491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004328934,"about_ca_topic_score_gemma":0.0008146064,"domain_scores_codex":[0.999964,0.000009520156,0.000001628303,0.000004854988,0.000009728314,0.00001012221],"domain_scores_gemma":[0.9999678,0.000006965985,0.0000090854,0.000002511948,0.000004075059,0.000009600132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001435124,0.00002375364,0.0009287797,0.00004520443,0.000004386211,0.00004249132,0.00001294578,0.0001549202,0.9907231,0.000275362,0.0000897115,0.00755595],"study_design_scores_gemma":[0.00001594908,0.0006477996,0.01950998,0.00001193551,0.00001606944,0.0004943251,0.00004522586,0.001226837,0.9715264,0.0003402404,0.006160656,0.000004400666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852211,0.009993588,0.001687691,0.0002218475,0.00001865513,0.00001333629,0.00009522479,0.00005321695,0.002695342],"genre_scores_gemma":[0.9960971,0.002241503,0.0004325965,0.00004898112,0.000007518715,0.000004318599,0.00007063357,0.000003277012,0.001094076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005983194,"threshold_uncertainty_score":0.002001524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02188477063841132,"score_gpt":0.3022325264846977,"score_spread":0.2803477558462864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}