{"id":"W4392515719","doi":"10.3389/fimmu.2024.1360629","title":"High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment","year":2024,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Hypoxia (environmental); Pancreatic cancer; Biology; Immune system; Gene signature; Cancer research; Tumor microenvironment; Gene expression profiling; Reprogramming; Transcriptome; Gene expression; Immunology; Gene; Internal medicine; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000210918,0.0003278187,0.0008510167,0.0004593922,0.00006124532,0.0000119071,0.0003349158,0.0004327419,0.0005931864],"category_scores_gemma":[0.00006243738,0.0002826824,0.0000823095,0.0003727886,0.0006983914,0.0001250282,0.0001055105,0.0006968143,0.00002193809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005118552,"about_ca_system_score_gemma":0.0002259589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005264984,"about_ca_topic_score_gemma":0.002287567,"domain_scores_codex":[0.9974357,0.0004765941,0.0005876225,0.0006265033,0.00004435469,0.0008291673],"domain_scores_gemma":[0.9991776,0.0001552663,0.000203451,0.0004047846,0.00003582305,0.00002307932],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002733456,0.0007567211,0.4243518,0.00008523857,0.002345478,0.0002413393,0.003635243,0.0001978974,0.5447335,0.0001112841,0.004327423,0.01648068],"study_design_scores_gemma":[0.006941506,0.001656832,0.8739156,0.0006340398,0.0001704403,0.00010494,0.002147498,0.0001520302,0.09982327,0.0004542399,0.01337627,0.0006233311],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9299725,0.06670059,0.00007981559,0.0001317895,0.002307083,0.0003907572,0.0002790836,0.00004623476,0.0000921734],"genre_scores_gemma":[0.9955968,0.002492043,0.0004861515,0.0001268433,0.00001530438,0.0002369409,0.0002867357,0.00004348041,0.0007157573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4495638,"threshold_uncertainty_score":0.9999625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00433896788978095,"score_gpt":0.2034466360689874,"score_spread":0.1991076681792064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}