{"id":"W4392515843","doi":"10.1002/jia2.26223","title":"Phase 1 randomized pharmacokinetic and safety study of a 90‐day tenofovir vaginal ring in the United States","year":2024,"lang":"en","type":"article","venue":"Journal of the International AIDS Society","topic":"Reproductive tract infections research","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kensington Health","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institute of Mental Health; U.S. President’s Emergency Plan for AIDS Relief","keywords":"Medicine; Vaginal ring; Placebo; Microbicide; Pharmacokinetics; Microbicides for sexually transmitted diseases; Vaginal microbicide; Pre-exposure prophylaxis; Adverse effect; Randomized controlled trial; Tenofovir; Internal medicine; Human immunodeficiency virus (HIV); Population; Family planning; Virology; Men who have sex with men","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00205044,0.001043839,0.001882197,0.000302642,0.0004167735,0.0008336636,0.0006860531,0.001296022,0.006613669],"category_scores_gemma":[0.001791513,0.0009247701,0.0009182771,0.0003448368,0.0007581089,0.0007576749,0.0003272182,0.00210193,0.0008948602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009856457,"about_ca_system_score_gemma":0.001948629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372339,"about_ca_topic_score_gemma":0.003094457,"domain_scores_codex":[0.9992087,0.0004484788,0.00003368175,0.0001412853,0.00007495248,0.00009293684],"domain_scores_gemma":[0.999055,0.0001631775,0.0002614119,0.00008929407,0.00009521662,0.0003359382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9366477,0.02432756,0.002271165,0.0004086066,0.0008461562,0.00006765399,0.0001247413,0.0003818913,0.006880241,0.000133749,0.002319843,0.02559078],"study_design_scores_gemma":[0.8199441,0.1722311,0.004595799,0.00003387699,0.0003908434,0.00008336914,0.00003257868,0.0004977513,0.0007314035,0.0001137958,0.001326062,0.00001929581],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860559,0.002738826,0.001096013,0.0007365398,0.0003269099,0.005806867,0.001521404,0.0001581423,0.001559533],"genre_scores_gemma":[0.9869763,0.001844072,0.001812549,0.001091404,0.0001623835,0.004593329,0.001069978,0.00002903036,0.002421053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006613669,"threshold_uncertainty_score":0.02212495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044548123374803,"score_gpt":0.3528754637009975,"score_spread":0.3324299824672495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}