{"id":"W4392520531","doi":"10.1021/acsinfecdis.4c00049","title":"Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of <i>Pseudomonas aeruginosa</i> A-Band Polysaccharide and Immunogenicity Evaluation for the Continued Development of a Potential Glycoconjugate Vaccine","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Glycoconjugate; Immunogenicity; Pseudomonas aeruginosa; Microbiology; Conjugate vaccine; Immune system; Pathogen; Tetrasaccharide; Polysaccharide; Biology; Bacteria; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002730409,0.00008862648,0.0001442635,0.00002435725,0.0001518586,0.00001973242,0.0001030157,0.00003301039,0.00008187874],"category_scores_gemma":[0.0001942085,0.0000506643,0.00008592994,0.0001565259,0.0001726258,0.0001244906,0.00009692201,0.00004184865,2.413844e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003967638,"about_ca_system_score_gemma":0.00004936508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004413959,"about_ca_topic_score_gemma":0.0001831112,"domain_scores_codex":[0.9992329,0.00008814174,0.0003206858,0.0001356332,0.0001479439,0.0000746869],"domain_scores_gemma":[0.9992186,0.0002730641,0.0002634748,0.0001637469,0.00006405578,0.00001709235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008389508,0.00008350061,0.007761763,0.00009142705,0.0001500597,4.152513e-8,0.0005167351,0.003879921,0.9761229,0.00003099909,0.00003888079,0.01123987],"study_design_scores_gemma":[0.0004215622,0.00003896659,0.2438378,0.0001241103,0.0006398854,0.000006252564,0.00009653136,0.00408149,0.7504814,0.0001418546,0.00006242473,0.00006771358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964974,0.0006151694,0.001731803,0.0001393417,0.0001737941,0.0007006571,0.0001010721,0.000007065139,0.00003372908],"genre_scores_gemma":[0.9996541,0.0001243015,0.0001069578,0.00001831293,0.00001088078,0.00005810015,0.000003852804,0.000007658803,0.00001590421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.236076,"threshold_uncertainty_score":0.206603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007099516807855194,"score_gpt":0.2340913049624664,"score_spread":0.2269917881546112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}