{"id":"W4392520531","doi":"10.1021/acsinfecdis.4c00049","title":"Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of <i>Pseudomonas aeruginosa</i> A-Band Polysaccharide and Immunogenicity Evaluation for the Continued Development of a Potential Glycoconjugate Vaccine","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"National Research Council Canada","keywords":"Glycoconjugate; Immunogenicity; Pseudomonas aeruginosa; Microbiology; Conjugate vaccine; Immune system; Pathogen; Tetrasaccharide; Polysaccharide; Biology; Bacteria; Chemistry; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003611871,0.0003018441,0.0001426387,0.000124621,0.0001236912,0.0002367996,0.0001629773,0.0002370643,0.0004004923],"category_scores_gemma":[0.0002638205,0.0001086145,0.0002358525,0.0001603188,0.0001153495,0.0002144082,0.000152715,0.00029296,0.0002044792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002478923,"about_ca_system_score_gemma":0.0003301836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004983758,"about_ca_topic_score_gemma":0.0008339671,"domain_scores_codex":[0.9998281,0.00004343715,0.00002097973,0.00002591214,0.00004841699,0.00003313976],"domain_scores_gemma":[0.9998857,0.00001508591,0.00004277116,0.00001492415,0.00002507626,0.00001649253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002942166,0.00002010068,0.00006644971,0.00002558556,0.000002646008,0.00002683641,0.00001209967,0.0002980189,0.9983632,0.00008062799,0.00001357176,0.001061493],"study_design_scores_gemma":[0.000003665463,0.0002009746,0.0003747116,0.000002299774,0.000005199493,0.00003878236,0.000008527628,0.0006449333,0.9978166,0.00001615304,0.0008842103,0.000003981696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867715,0.0002525178,0.01149678,0.00007229052,0.00001531106,0.0001311089,0.0001374962,0.00003817404,0.001084782],"genre_scores_gemma":[0.9709098,0.0006145872,0.0267082,0.00004208911,0.000007270497,0.00009101379,0.0002702396,0.00003166001,0.001325071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004983758,"threshold_uncertainty_score":0.00191015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007099516807855194,"score_gpt":0.2340913049624664,"score_spread":0.2269917881546112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}