{"id":"W4392543343","doi":"10.1182/blood.2023022589","title":"Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"BioMarin Pharmaceutical; CSL Behring; Novo Nordisk; Sanofi; Pfizer","keywords":"Gene transfer; Vector (molecular biology); Virology; Medicine; Biology; Immunology; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001958328,0.00009161434,0.00006334614,0.00004300881,0.0000211266,0.00005100874,0.000108039,0.00008241001,0.0000294246],"category_scores_gemma":[0.00001326583,0.00006751924,0.00004522262,0.00009396584,0.00004876336,0.000004021991,0.0000244273,0.0001166447,0.00001911518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005117574,"about_ca_system_score_gemma":0.00003125662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002524943,"about_ca_topic_score_gemma":0.0004476709,"domain_scores_codex":[0.9993224,0.00008157192,0.00009181855,0.0002391708,0.0001084882,0.0001565969],"domain_scores_gemma":[0.9997438,0.00001633061,0.000003985558,0.0001893733,0.00001627844,0.00003018931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002108505,0.00008230494,0.0008319907,0.0000176365,0.00003835649,0.00007467549,0.0005350786,0.000002673568,0.9921964,0.00001041738,0.00007055228,0.005929073],"study_design_scores_gemma":[0.001051577,0.0007306883,0.01908961,0.00002340085,0.00002698775,0.00003499341,0.00004867654,0.0002077568,0.9757272,0.00004086363,0.002867893,0.0001503652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935424,0.005838748,0.00009696812,0.0001831827,0.00004207196,0.0002057739,0.00002819107,0.000009099441,0.00005358936],"genre_scores_gemma":[0.9986832,0.0006654047,0.00006631212,0.0001926064,0.0001484354,0.000065737,0.00003817811,0.00001802951,0.0001221592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01825762,"threshold_uncertainty_score":0.2753355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176305389220959,"score_gpt":0.2576919423836133,"score_spread":0.2459288884914037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}