{"id":"W4392543343","doi":"10.1182/blood.2023022589","title":"Vector integration and fate in the hemophilia dog liver multiple years after AAV-FVIII gene transfer","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"BioMarin Pharmaceutical; CSL Behring; Novo Nordisk; Sanofi; Pfizer","keywords":"Gene transfer; Vector (molecular biology); Virology; Medicine; Biology; Immunology; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002606689,0.00009522431,0.0002312283,0.0005390761,0.0001605841,0.0003895667,0.0001221367,0.000350376,0.001294527],"category_scores_gemma":[0.0002765489,0.0001125978,0.0001020133,0.0001932347,0.0002165306,0.0002680963,0.0002010369,0.0002622288,0.0004919129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002153252,"about_ca_system_score_gemma":0.0001213584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004031947,"about_ca_topic_score_gemma":0.0004258314,"domain_scores_codex":[0.9998216,0.00002368934,0.00001465439,0.00004534813,0.00006091233,0.00003376891],"domain_scores_gemma":[0.9997452,0.00005952172,0.0000739282,0.0000257218,0.00004568854,0.00004998103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004241478,0.00005883073,0.01141084,0.00002674638,0.0000114883,0.0004898,0.0001323214,0.00007431258,0.9819521,0.0001746307,0.00004915679,0.005195653],"study_design_scores_gemma":[0.00003510399,0.002439967,0.2098867,0.00002321799,0.00008059773,0.009433053,0.0004547458,0.002879685,0.7695445,0.0003467366,0.004843279,0.00003232999],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971278,0.0005553343,0.001535653,0.00001359645,0.000005522773,0.00001023105,0.0001035112,0.00002751573,0.0006207944],"genre_scores_gemma":[0.997645,0.0001471027,0.0004992193,0.000009455816,0.000003347099,0.00001167581,0.0002781267,0.000007473236,0.00139868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001294527,"threshold_uncertainty_score":0.004330635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176305389220959,"score_gpt":0.2576919423836133,"score_spread":0.2459288884914037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}