{"id":"W4392545376","doi":"10.1016/s2666-5247(24)00003-x","title":"System-wide approaches to antimicrobial therapy and antimicrobial resistance in the UK: the AMR-X framework","year":2024,"lang":"en","type":"review","venue":"The Lancet Microbe","topic":"Antibiotic Use and Resistance","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"North Bristol NHS Trust; University of Bristol; Queen's University Belfast; Medical Research Council; Cardiff University; University College London; Queen Mary University of London; University of Dundee; Imperial College London; Queen's University; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; University of Leicester; Marie Curie; University of Leeds; National Institute for Health and Care Research; National Institute for Health and Care Excellence; Johns Hopkins University; Pfizer","keywords":"Antimicrobial; Antibiotic resistance; Medicine; Microbiology; Biology; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.001891139,0.0008644134,0.002187849,0.0001637815,0.0006768291,0.0003090724,0.002533536,0.0008713034,0.00002737695],"category_scores_gemma":[0.00008274188,0.0003568528,0.0004965015,0.000871145,0.000833938,0.0000438526,0.0005132256,0.002504025,0.0007570688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001038619,"about_ca_system_score_gemma":0.0002014802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009084678,"about_ca_topic_score_gemma":0.0003584369,"domain_scores_codex":[0.9955162,0.001542886,0.000887776,0.0009497141,0.00009106407,0.001012343],"domain_scores_gemma":[0.9966351,0.001196538,0.0003665104,0.001744611,0.00002954411,0.00002764193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006104925,0.0002353058,0.00008052381,0.03019485,0.002308588,0.0001730455,0.01079664,0.00000254504,0.001133689,0.0349616,0.8712524,0.04825035],"study_design_scores_gemma":[0.0003577669,0.00002943839,0.0000448544,0.02172617,0.0005931676,0.0003256105,0.0003554069,1.206291e-7,0.0001317906,0.0001200932,0.9758149,0.0005007159],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001047935,0.9866677,0.00007261836,0.006850892,0.001461912,0.002402785,0.00033766,0.000109825,0.001048664],"genre_scores_gemma":[0.005378509,0.9870853,0.0002512107,0.003531875,0.000751703,0.00009532856,0.00009937266,0.0001080206,0.002698668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1045625,"threshold_uncertainty_score":0.9998884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1047541582864941,"score_gpt":0.2925511388566044,"score_spread":0.1877969805701103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}