{"id":"W4392546039","doi":"10.1016/j.gep.2024.119357","title":"Transcriptional regulation of the alternative sex hormone-binding globulin promoter by KLF4","year":2024,"lang":"en","type":"article","venue":"Gene Expression Patterns","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"Biology; Sex hormone-binding globulin; Gene knockdown; Transcriptional regulation; Promoter; KLF4; Alternative splicing; Transcription factor; Cell biology; Exon; Endocrinology; Genetics; Gene; Hormone; Gene expression; Androgen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923892,0.0003322579,0.0002109506,0.0005748839,0.0002019503,0.0004606893,0.0002337471,0.000199859,0.001913298],"category_scores_gemma":[0.000199799,0.00025967,0.0003228662,0.0001745125,0.0003895758,0.0002497947,0.0004005828,0.0005273573,0.0006561289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005730557,"about_ca_system_score_gemma":0.0002805606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001717708,"about_ca_topic_score_gemma":0.00280165,"domain_scores_codex":[0.9997995,0.00003716886,0.00001326459,0.00005378412,0.00003992454,0.00005637011],"domain_scores_gemma":[0.9997876,0.00004567122,0.00004128692,0.0000267154,0.00004022407,0.00005859247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000131441,0.000008685513,0.0005795723,0.00001232493,0.000004185452,0.000046212,0.00002389269,0.00003771088,0.9978358,0.0002877928,0.00003459416,0.0009977648],"study_design_scores_gemma":[0.00002858569,0.0001110781,0.02831154,0.00001683173,0.00001877066,0.0003003277,0.0001704474,0.001771295,0.9654052,0.0003462188,0.003505843,0.00001380627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990067,0.001091176,0.005875873,0.0001082594,0.00003451718,0.0000128513,0.0004838683,0.0001052482,0.00222118],"genre_scores_gemma":[0.9899143,0.0003004046,0.002553371,0.00008633945,0.00001239871,0.00001724138,0.0009150596,0.00006062609,0.006140294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001913298,"threshold_uncertainty_score":0.006400645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497722487148483,"score_gpt":0.2781354522504833,"score_spread":0.2631582273789985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}