{"id":"W4392546518","doi":"10.1016/j.cjca.2024.03.004","title":"Rejuvenation of the Aging Heart: Molecular Determinants and Applications","year":2024,"lang":"en","type":"review","venue":"Canadian Journal of Cardiology","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Medicine; Rejuvenation; Disease; Population ageing; Population; Successful aging; Gerontology; Longevity; Dementia; Parabiosis; Bioinformatics; Intensive care medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007631175,0.0008063883,0.001644926,0.001487056,0.0002840407,0.001263085,0.0007994614,0.001298048,0.00369202],"category_scores_gemma":[0.0009962,0.0002398156,0.0006334761,0.001382662,0.0006506389,0.0008300391,0.00058595,0.002127855,0.001138383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006400791,"about_ca_system_score_gemma":0.001513752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002148271,"about_ca_topic_score_gemma":0.006280804,"domain_scores_codex":[0.9998385,0.00002783235,0.00002159279,0.00003395668,0.00005848224,0.00001965871],"domain_scores_gemma":[0.9995461,0.0002316347,0.00005561168,0.00001319707,0.0001126894,0.00004062194],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002567481,0.0001268288,0.0004030527,0.01907221,0.0002565648,0.0002143135,0.00008001006,0.0004249304,0.003147524,0.006767139,0.02597458,0.9432762],"study_design_scores_gemma":[0.00009018311,0.0002780769,0.002878073,0.005872282,0.0004622235,0.0009288522,0.0001486216,0.0002193263,0.001174095,0.004820759,0.9830806,0.00004692996],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009369436,0.9989859,0.00005658223,0.0002716537,0.0001618747,0.000002327463,0.00001222946,0.000003240513,0.0004124581],"genre_scores_gemma":[0.0007139994,0.9985744,0.00009044608,0.0001383306,0.0002193157,0.000003450603,0.00001653168,6.457832e-7,0.0002429901],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00369202,"threshold_uncertainty_score":0.0123511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02372761159211232,"score_gpt":0.3327935736561968,"score_spread":0.3090659620640844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}