{"id":"W4392550980","doi":"10.1186/s40478-024-01751-w","title":"Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Bone Tumor Diagnosis and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Institute of Cancer Research; Ontario Ministry of Health and Long-Term Care; Chordoma Foundation","keywords":"Organelle; Proteomics; Biology; Cell; Computational biology; Neuroscience; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001821793,0.0004029211,0.00027045,0.0004155875,0.0001958348,0.0004320423,0.0001995764,0.0002741215,0.0005322638],"category_scores_gemma":[0.000216309,0.0001219356,0.000346829,0.0002455925,0.0001911685,0.0001972619,0.0002668628,0.0004027295,0.0004167038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003707786,"about_ca_system_score_gemma":0.0002090987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008445297,"about_ca_topic_score_gemma":0.001224658,"domain_scores_codex":[0.9998651,0.0000116541,0.00001233865,0.0000458778,0.00003988899,0.00002502045],"domain_scores_gemma":[0.9998697,0.00001922235,0.00003296201,0.00002147409,0.00003190141,0.00002465541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004205585,0.000003289943,0.0008983601,0.00001564779,0.000004996954,0.00007408181,0.00001010672,0.0000328418,0.9982775,0.0000162411,0.0000278493,0.0005969791],"study_design_scores_gemma":[0.00001198955,0.0001675325,0.05670305,0.000009092438,0.00005565556,0.001755362,0.0001377975,0.002617626,0.9342927,0.00009750841,0.004137407,0.0000141625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907745,0.001153139,0.005625195,0.0001285718,0.00002055911,0.00002229173,0.001469993,0.0001370854,0.000668757],"genre_scores_gemma":[0.9889842,0.0007775386,0.005815811,0.00009492245,0.000009047354,0.00002496759,0.0029207,0.0000419352,0.00133087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008445297,"threshold_uncertainty_score":0.002690256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04779064274815875,"score_gpt":0.3025471426536777,"score_spread":0.2547564999055189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}