{"id":"W4392551074","doi":"10.1038/s41380-024-02468-x","title":"Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial","year":2024,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Transcranial Magnetic Stimulation Studies","field":"Neuroscience","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Manitoba","funders":"National Institute on Drug Abuse; National Institute on Aging; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; H. Lundbeck A/S; Vistagen Therapeutics; Cerecor; Marinus Pharmaceuticals; Neurocrine Biosciences; ACADIA Pharmaceuticals; Congressionally Directed Medical Research Programs; Idorsia Pharmaceuticals; Arbor Pharmaceuticals; Weston Brain Institute; Michael Smith Health Research BC; UCB Pharma; Stanley Medical Research Institute; BioClinica; Pfizer; Northwestern University; Biogen; Science Foundation Ireland; Massachusetts General Hospital; Sanofi; Fondation Brain Canada; Vancouver Coastal Health Research Institute; Shire; Janssen Pharmaceuticals; BrainsWay; Eli Lilly and Company; Allergan; AstraZeneca; National Institute of Mental Health; Avanir Pharmaceuticals; Patient-Centered Outcomes Research Institute","keywords":"Venlafaxine; Aripiprazole; Transcranial magnetic stimulation; Antidepressant; Randomized controlled trial; Depression (economics); Psychology; Major depressive episode; Venlafaxine Hydrochloride; Medicine; Treatment-resistant depression; Internal medicine; Mood; Psychiatry; Stimulation; Schizophrenia (object-oriented programming); Anxiety","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0117003,0.001645699,0.005103272,0.0008954834,0.0006289312,0.001333188,0.001030628,0.003237629,0.012523],"category_scores_gemma":[0.01577988,0.0007865911,0.002872557,0.000725503,0.001444184,0.00171943,0.0007852527,0.002732346,0.001027404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007947857,"about_ca_system_score_gemma":0.001217668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000553146,"about_ca_topic_score_gemma":0.000946272,"domain_scores_codex":[0.9838308,0.01361919,0.0008300513,0.0007307357,0.0005432871,0.0004459874],"domain_scores_gemma":[0.9916591,0.004512438,0.001770052,0.0007490408,0.0004361298,0.0008732755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.98844,0.001343,0.0003908697,0.001127201,0.001789874,0.00003281599,0.00002746118,0.0001160343,0.0003721033,0.0003732264,0.0004217962,0.005565572],"study_design_scores_gemma":[0.9787974,0.01915829,0.000495224,0.00006384784,0.0005013584,0.00001832463,0.00001137286,0.0002288442,0.00005159089,0.0001772571,0.0004897285,0.000006700887],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8814624,0.02418041,0.007109812,0.00297867,0.004413724,0.06322934,0.004283484,0.0005041912,0.01183797],"genre_scores_gemma":[0.9091357,0.005974822,0.01022711,0.002593516,0.001575198,0.06409837,0.001850406,0.0000436583,0.0045012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.012523,"threshold_uncertainty_score":0.06187785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1470093837119768,"score_gpt":0.4642508758664794,"score_spread":0.3172414921545026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}