{"id":"W4392557907","doi":"10.1186/s13063-024-07982-5","title":"IA-PACS-CFS: a double-blinded, randomized, sham-controlled, exploratory trial of immunoadsorption in patients with chronic fatigue syndrome (CFS) including patients with post-acute COVID-19 CFS (PACS-CFS)","year":2024,"lang":"en","type":"article","venue":"Trials","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Charité – Universitätsmedizin Berlin; Bundesministerium für Bildung und Forschung","keywords":"Medicine; Chronic fatigue syndrome; Randomized controlled trial; Internal medicine; Immunoadsorption; Tolerability; Placebo; myalgia; Immunology; Adverse effect; Antibody; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002026853,0.002720618,0.004089198,0.000754428,0.0008485929,0.001178209,0.001191652,0.003385998,0.008213475],"category_scores_gemma":[0.002056726,0.0007978365,0.001759212,0.0005063714,0.002029943,0.001304714,0.0006233711,0.002849141,0.001201352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007203786,"about_ca_system_score_gemma":0.001589963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009022425,"about_ca_topic_score_gemma":0.001574288,"domain_scores_codex":[0.9991209,0.0004132974,0.0000584251,0.0001740883,0.00005255134,0.0001807387],"domain_scores_gemma":[0.9987789,0.0002958519,0.0002570111,0.000113911,0.0000954848,0.0004588085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9844338,0.008613669,0.000129219,0.000332958,0.0002180804,0.00001813195,0.00002577173,0.0001103046,0.001288496,0.00006022688,0.0002251445,0.004544285],"study_design_scores_gemma":[0.9208131,0.07821652,0.0003650626,0.00001644562,0.0001056392,0.000009976526,0.00001161123,0.0001051206,0.0001215921,0.00005332871,0.0001743047,0.000007364167],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781547,0.004323495,0.0007953444,0.0008469021,0.001344704,0.01146387,0.0008671384,0.0001837294,0.00202022],"genre_scores_gemma":[0.971604,0.002111896,0.002487547,0.001363159,0.0008958909,0.01786301,0.0007361081,0.00001771953,0.00292061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008213475,"threshold_uncertainty_score":0.02747685,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0937607569442525,"score_gpt":0.3898748511397702,"score_spread":0.2961140941955177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}