{"id":"W4392560887","doi":"10.1038/s41591-024-02854-6","title":"Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury","year":2024,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; Population Health Research Institute; Impact; Queen's University","funders":"CIHR Skin Research Training Centre; National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Gillings School of Public Health; National Institute on Aging; Government of Canada; Deutsche Forschungsgemeinschaft; National Institute on Minority Health and Health Disparities; Physicians' Services Incorporated Foundation; National Institutes of Health; U.S. Department of Health and Human Services; Broad Institute; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Acute kidney injury; Medicine; Mendelian randomization; Proinflammatory cytokine; Dialysis; Kidney disease; Population; Internal medicine; Oncology; Biology; Inflammation; Gene; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004183426,0.0001556677,0.000168017,0.0005989136,0.0001624093,0.0002791399,0.0001919877,0.0002081344,0.001172276],"category_scores_gemma":[0.001040102,0.00008817141,0.0001307712,0.0003267677,0.0002340184,0.000129224,0.0002901592,0.000321726,0.00006801615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001319097,"about_ca_system_score_gemma":0.0001410781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002181077,"about_ca_topic_score_gemma":0.0002895261,"domain_scores_codex":[0.9997846,0.00006988039,0.0000153199,0.0000422952,0.0000603414,0.00002756104],"domain_scores_gemma":[0.9984517,0.0002656889,0.0008240726,0.000121776,0.0001058841,0.0002307464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00113817,0.0001004891,0.9108875,0.00007109642,0.0001098675,0.0008836928,0.00006267611,0.0002870607,0.07214644,0.0005385001,0.0002690069,0.01350555],"study_design_scores_gemma":[0.00001327652,0.0002653871,0.9830578,0.00001150422,0.00005962358,0.003180247,0.00005170764,0.000888999,0.01116582,0.0005310929,0.0007665408,0.000008033968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980615,0.0004432652,0.000983463,0.00004866083,0.000005658836,0.000005278777,0.0001006683,0.00001507715,0.0003364014],"genre_scores_gemma":[0.9994697,0.0000852259,0.0002786487,0.00001633619,0.000007054295,0.000002170199,0.00004946261,0.000001750632,0.00008968205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001172276,"threshold_uncertainty_score":0.003921628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005648820251525019,"score_gpt":0.2904209626098934,"score_spread":0.2847721423583683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}