{"id":"W4392578268","doi":"10.1101/2024.03.05.583412","title":"Single-cell analysis of an engineered organoid-based model of pancreatic cancer identifies hypoxia as a contributing factor in the determination of transcriptional subtypes","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Organoid; Transcriptome; Biology; Phenotype; Tumor microenvironment; Hypoxia (environmental); Pancreatic cancer; Cancer research; Cancer cell; Cell biology; Cell; Gene expression; Gene; Cancer; Tumor cells; Chemistry; Genetics; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723538,0.0002075642,0.0002860348,0.0001603908,0.0001479533,0.0004247809,0.0001599574,0.0002527577,0.0005745044],"category_scores_gemma":[0.00009837547,0.0001175975,0.000250099,0.000168041,0.0002364316,0.0001538956,0.0002512452,0.0005642384,0.0001846294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003406383,"about_ca_system_score_gemma":0.0002093145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009910789,"about_ca_topic_score_gemma":0.001115327,"domain_scores_codex":[0.9998798,0.0000139367,0.000007372688,0.00004609609,0.00003749499,0.00001520018],"domain_scores_gemma":[0.9998785,0.00003206017,0.00002955705,0.00002009629,0.00001353614,0.00002618043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003076952,0.000006684932,0.0001923838,0.000009231049,0.000001878378,0.0000118809,0.00001306767,0.0003083457,0.9991085,0.0000420754,0.00001229611,0.000262861],"study_design_scores_gemma":[0.000005390268,0.0001084748,0.004407552,0.000003424499,0.000009012962,0.00005117881,0.00006140603,0.006767246,0.9873787,0.00006533247,0.00113557,0.000006676551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707334,0.0003530855,0.0266265,0.00005513418,0.00002756403,0.00002976139,0.001207917,0.00012425,0.0008423294],"genre_scores_gemma":[0.9830087,0.0002880751,0.0131072,0.00003665864,0.000003541006,0.0000614554,0.001024816,0.00005212838,0.00241747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009910789,"threshold_uncertainty_score":0.002471507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03176333261500233,"score_gpt":0.2880085623699231,"score_spread":0.2562452297549208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}