{"id":"W4392578361","doi":"10.1101/2024.03.07.24303870","title":"A Large-Scale Genome-Wide Study of Gene-Sleep Duration Interactions for Blood Pressure in 811,405 Individuals from Diverse Populations","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Sleep and related disorders","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; University of Toronto; Université Laval","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Blood pressure; Sleep (system call); Population; Duration (music); Biology; Gene; Genome; Bioinformatics; Genetics; Medicine; Endocrinology; Computer science; Environmental health","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001131654,0.0004174188,0.0004414101,0.0005546969,0.0009233864,0.0005247136,0.0003151868,0.0004930464,0.001628131],"category_scores_gemma":[0.00150972,0.0002514777,0.0005810338,0.001161708,0.0003782526,0.0001691198,0.0005811562,0.0005714116,0.0002270228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002676713,"about_ca_system_score_gemma":0.000426643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009776348,"about_ca_topic_score_gemma":0.01488662,"domain_scores_codex":[0.999334,0.0002194859,0.00003330206,0.0002519148,0.00007658067,0.00008452185],"domain_scores_gemma":[0.9992697,0.0002924704,0.000118504,0.0001580294,0.00004095749,0.0001203215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008748136,0.0001484262,0.9524552,0.00006776524,0.001217573,0.0008636123,0.001468398,0.0003848268,0.02907708,0.0003084271,0.0008714554,0.0122625],"study_design_scores_gemma":[0.00002785647,0.0000818143,0.9982268,0.000004548784,0.0001267023,0.000204492,0.0001466656,0.0001483197,0.0003429649,0.00008891799,0.0005942663,0.000006608603],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997668,0.0001483049,0.0007819519,0.00006566881,0.000004536216,0.00001104236,0.0009931814,0.00001065534,0.0003166354],"genre_scores_gemma":[0.9965929,0.0001182678,0.001142696,0.0000908909,0.00001487569,0.00002867648,0.001336809,0.000009685482,0.0006651733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009776348,"threshold_uncertainty_score":0.01943892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03486351232393251,"score_gpt":0.3252466380410187,"score_spread":0.2903831257170861,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}