{"id":"W4392581822","doi":"10.21203/rs.3.rs-3616020/v1","title":"Dynamic Covalent Disulfide Exchange Mediates Oral Delivery of Biomacromolecules","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Basic Energy Sciences; Zhejiang University; National Natural Science Foundation of China; National Key Research and Development Program of China; U.S. Department of Energy","keywords":"Disulfide bond; Covalent bond; Chemistry; Business; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.003717835,0.0005983131,0.0009320551,0.001148539,0.0002514583,0.00007522015,0.001193062,0.001295474,0.001268929],"category_scores_gemma":[0.0004017795,0.0005629837,0.0004580157,0.0008017033,0.001040682,0.00008015244,0.004522365,0.004977335,0.001198556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006877966,"about_ca_system_score_gemma":0.0007188796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004080729,"about_ca_topic_score_gemma":0.0003264212,"domain_scores_codex":[0.992384,0.002853499,0.0009493911,0.001189279,0.001332171,0.001291646],"domain_scores_gemma":[0.9955673,0.001703372,0.0002839788,0.0009215184,0.001017227,0.0005066422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005166317,0.005103308,0.01418672,0.1291299,0.009457573,0.01059876,0.02120362,0.01881101,0.3697768,0.005679708,0.1369303,0.2739559],"study_design_scores_gemma":[0.007316384,0.002564484,0.005086339,0.01301759,0.00188029,0.0002805944,0.008686397,0.1797384,0.2010754,0.0618677,0.5131137,0.005372682],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094169,0.07544458,0.0001217216,0.001068543,0.004075211,0.002685275,0.004297717,0.000318815,0.002571307],"genre_scores_gemma":[0.9840645,0.01158794,0.0003369187,0.00006978676,0.0003290312,0.0006087411,0.0006532257,0.0001469445,0.002202937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3761834,"threshold_uncertainty_score":0.9996822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1874367271309523,"score_gpt":0.5280787108670479,"score_spread":0.3406419837360957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}