{"id":"W4392582100","doi":"10.1101/2024.03.06.24303776","title":"Genome-wide association study identifies new loci associated with OCD","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"University of California, Los Angeles; National Institutes of Health; Instituto Nacional de Medicina Genómica; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Norwegian Institute of Public Health; Haukeland Universitetssjukehus; Rheinische Friedrich-Wilhelms-Universität Bonn; Tartu Ülikool; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universitetet i Bergen; Fudan University; Albert-Ludwigs-Universität Freiburg; University of New South Wales; Instituto de Salud Carlos III; Universitat de Barcelona; Göteborgs Universitet; Koninklijke Nederlandse Akademie van Wetenschappen; Rijksuniversiteit Groningen; Karolinska Institutet; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale; Department of Psychiatry, Columbia University; Johns Hopkins Bloomberg School of Public Health; Vanderbilt University; Universitetet i Oslo; Amsterdam University Medical Centers; Norges Teknisk-Naturvitenskapelige Universitet; National Institute of Mental Health; Aarhus Universitet; Broad Institute; Universität zu Köln; Dalhousie University; National Health Research Institutes; Vanderbilt University Medical Center; University of Pittsburgh; University of Sydney; Johns Hopkins University; University of North Carolina at Chapel Hill; Universiteit Stellenbosch; Helsingin Yliopisto; Brown University; Georg-August-Universität Göttingen; Assistance publique-Hôpitaux de Paris; Massachusetts General Hospital","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Heritability; Genetic association; SNP; Biology; Genetics; Missing heritability problem; Genetic architecture; Gene; Quantitative trait locus; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009929563,0.0007222375,0.00097327,0.000486394,0.0001492488,0.0003708779,0.0009057533,0.0006758223,0.002387791],"category_scores_gemma":[0.0008407847,0.0006799893,0.0003088801,0.0007010095,0.00007689636,0.0000691828,0.0009427992,0.002141278,0.00307572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001042064,"about_ca_system_score_gemma":0.0003552482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002032141,"about_ca_topic_score_gemma":0.004499334,"domain_scores_codex":[0.9951088,0.0007610557,0.0007545481,0.001558452,0.0009861205,0.0008310417],"domain_scores_gemma":[0.9967976,0.0006637652,0.0009314739,0.001151911,0.0002550516,0.0002001602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00006157858,0.00070754,0.9638829,0.00007149907,0.004374185,0.0003639055,0.01493966,0.0001152528,0.00003067606,0.0001179273,0.01513361,0.0002012594],"study_design_scores_gemma":[0.001342669,0.0002362048,0.98094,0.000130427,0.0008764632,0.000001203884,0.003520614,0.00001008654,0.00001601224,0.010865,0.001332765,0.0007285712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698479,0.001805095,0.00008936302,0.00353298,0.004189176,0.001721721,0.00007996473,0.0006833329,0.01805045],"genre_scores_gemma":[0.9197304,0.00001776278,0.00001996998,0.0002817882,0.000478334,0.0002117929,0.0002416961,0.0001989562,0.0788193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06076885,"threshold_uncertainty_score":0.9995651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770992585572737,"score_gpt":0.2940115263559738,"score_spread":0.2763016005002464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}