{"id":"W4392582100","doi":"10.1101/2024.03.06.24303776","title":"Genome-wide association study identifies new loci associated with OCD","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"University of California, Los Angeles; National Institutes of Health; Instituto Nacional de Medicina Genómica; Fundació Institut de Recerca Hospital Universitari Vall d’Hebron; Norwegian Institute of Public Health; Haukeland Universitetssjukehus; Rheinische Friedrich-Wilhelms-Universität Bonn; Tartu Ülikool; H. Lundbeck A/S; Deutsches Zentrum für Neurodegenerative Erkrankungen; Universitetet i Bergen; Fudan University; Albert-Ludwigs-Universität Freiburg; University of New South Wales; Instituto de Salud Carlos III; Universitat de Barcelona; Göteborgs Universitet; Koninklijke Nederlandse Akademie van Wetenschappen; Rijksuniversiteit Groningen; Karolinska Institutet; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale; Department of Psychiatry, Columbia University; Johns Hopkins Bloomberg School of Public Health; Vanderbilt University; Universitetet i Oslo; Amsterdam University Medical Centers; Norges Teknisk-Naturvitenskapelige Universitet; National Institute of Mental Health; Aarhus Universitet; Broad Institute; Universität zu Köln; Dalhousie University; National Health Research Institutes; Vanderbilt University Medical Center; University of Pittsburgh; University of Sydney; Johns Hopkins University; University of North Carolina at Chapel Hill; Universiteit Stellenbosch; Helsingin Yliopisto; Brown University; Georg-August-Universität Göttingen; Assistance publique-Hôpitaux de Paris; Massachusetts General Hospital","keywords":"Genome-wide association study; Single-nucleotide polymorphism; Heritability; Genetic association; SNP; Biology; Genetics; Missing heritability problem; Genetic architecture; Gene; Quantitative trait locus; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00110217,0.0003149711,0.000513968,0.001426568,0.0003533633,0.0008635819,0.0003744389,0.0005917109,0.002143755],"category_scores_gemma":[0.003918099,0.0002104634,0.001023406,0.002385864,0.0003703179,0.0002301235,0.0004916841,0.0006378274,0.0001979459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000219531,"about_ca_system_score_gemma":0.0003740487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005436542,"about_ca_topic_score_gemma":0.008185339,"domain_scores_codex":[0.9992077,0.000223739,0.00008307186,0.0002652156,0.000136494,0.00008383829],"domain_scores_gemma":[0.9976825,0.001040768,0.0006453256,0.0002229709,0.0001938776,0.0002145927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004874449,0.00004843089,0.9842679,0.00006668996,0.001405197,0.0004729762,0.000148447,0.0001400411,0.004976776,0.0001238702,0.0003139592,0.007548334],"study_design_scores_gemma":[0.00002572401,0.00004274196,0.9982268,0.000008653942,0.0003886324,0.0002913913,0.00006167134,0.0002011907,0.0001981184,0.0001143414,0.0004352823,0.000005487938],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995216,0.002008163,0.001029679,0.0002009847,0.00002320537,0.00001310762,0.0005683327,0.00004369099,0.0008966464],"genre_scores_gemma":[0.9976522,0.0006385852,0.0008078339,0.00008280374,0.00003116331,0.000009546968,0.0005396013,0.0000136388,0.0002245227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005436542,"threshold_uncertainty_score":0.01080978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01770992585572737,"score_gpt":0.2940115263559738,"score_spread":0.2763016005002464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}