{"id":"W4392582468","doi":"10.1016/s1470-2045(24)00070-6","title":"Activity of venetoclax in patients with relapsed or refractory chronic lymphocytic leukaemia: analysis of the VENICE-1 multicentre, open-label, single-arm, phase 3b trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Venetoclax; Open label; Medicine; Refractory (planetary science); Oncology; Internal medicine; Chronic lymphocytic leukemia; Clinical trial; Leukemia; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004294902,0.0006644331,0.001644241,0.0002815553,0.0002481932,0.0009964914,0.0006166465,0.0008111355,0.001699762],"category_scores_gemma":[0.001944507,0.000250318,0.001537214,0.0004078285,0.0006298909,0.0005032854,0.0003176711,0.001903902,0.0002468322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006673241,"about_ca_system_score_gemma":0.0009676039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004948534,"about_ca_topic_score_gemma":0.00153872,"domain_scores_codex":[0.9985171,0.001050292,0.00005940927,0.0001585239,0.0000932883,0.0001213215],"domain_scores_gemma":[0.9979493,0.0006728506,0.0005406489,0.0001823279,0.0001081806,0.000546692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9117914,0.005251965,0.02001517,0.001338297,0.003253884,0.0001137424,0.000167479,0.001320991,0.007401304,0.0002291399,0.0017399,0.04737669],"study_design_scores_gemma":[0.7265916,0.1980459,0.06596398,0.0001802968,0.002092614,0.0004720283,0.00008126038,0.001453627,0.001370142,0.0002613157,0.003440735,0.00004647649],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876984,0.009414792,0.0002094769,0.0002308597,0.00006360641,0.0007713851,0.0005812659,0.00002827715,0.001001925],"genre_scores_gemma":[0.9953671,0.00163102,0.0004195147,0.0002807945,0.0001086903,0.0005266374,0.001136344,0.000009697381,0.0005203404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004294902,"threshold_uncertainty_score":0.0227139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09800376265592863,"score_gpt":0.4116209237309606,"score_spread":0.313617161075032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}