{"id":"W4392588447","doi":"10.1038/s41467-024-46367-9","title":"Structural basis for self-discrimination by neoantigen-specific TCRs","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Argonne National Laboratory; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Melanoma Research Alliance; University of Chicago; National Institute of General Medical Sciences; Cancer Research Institute; York University; U.S. Department of Energy","keywords":"T-cell receptor; Avidity; Major histocompatibility complex; Epitope; Biology; T cell; Cytolysis; Immunogenicity; Computational biology; Antigen presentation; Cell biology; Antigen; Genetics; Cytotoxic T cell; Immune system; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006532078,0.0001401796,0.00009778363,0.00007338657,0.00008228409,0.0001626275,0.0001525189,0.0002171397,0.001375497],"category_scores_gemma":[0.0000794473,0.00007127695,0.0001395945,0.00004498042,0.0001451557,0.00008139434,0.0001257551,0.000252599,0.0003389101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001525622,"about_ca_system_score_gemma":0.0000923496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001905919,"about_ca_topic_score_gemma":0.0001447925,"domain_scores_codex":[0.9999563,0.000008131519,0.000002202493,0.000006903962,0.00001403278,0.00001249779],"domain_scores_gemma":[0.9999497,0.0000115169,0.00001267538,0.00000640826,0.000007448216,0.00001240776],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006487643,0.00001579456,0.0004033486,0.00001230091,0.000003133002,0.00008402459,0.000007502419,0.0003667766,0.9980397,0.0003518354,0.00001791307,0.0006328619],"study_design_scores_gemma":[0.00003226723,0.0004444678,0.008371094,0.000007666623,0.00001800699,0.0008478903,0.00005837538,0.00835439,0.9792442,0.0007078489,0.001907493,0.000006398548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963757,0.000191136,0.002268417,0.00003390304,0.000006443359,0.00000757518,0.00003227421,0.00002199422,0.001062458],"genre_scores_gemma":[0.9992498,0.00004597563,0.0004328495,0.00001222992,0.000001281159,0.000002482339,0.00004652494,0.000002993907,0.0002058917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375497,"threshold_uncertainty_score":0.004601479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05025525477717951,"score_gpt":0.3819615148023472,"score_spread":0.3317062600251677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}