{"id":"W4392588461","doi":"10.3390/cells13060480","title":"Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University","funders":"Health Canada; Harvard Stem Cell Institute; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"G protein-coupled receptor; Functional selectivity; Receptor; Allosteric regulation; Cannabinoid receptor; Signal transduction; Chemistry; Cell biology; Crosstalk; Cannabinoid; Cannabinoid Receptor Agonists; Allosteric modulator; Cell signaling; Biology; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003518243,0.0002424758,0.0004557286,0.0003337655,0.00005281412,0.00002186138,0.00005171062,0.0001158441,0.002260716],"category_scores_gemma":[0.0001016187,0.0002142799,0.0001044148,0.001222392,0.00004491774,0.0001018998,0.000005813364,0.0003692212,0.0001837801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003287593,"about_ca_system_score_gemma":0.0005442846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006940095,"about_ca_topic_score_gemma":0.00004399023,"domain_scores_codex":[0.9983398,0.000118424,0.0004011855,0.0004426029,0.000373894,0.0003240684],"domain_scores_gemma":[0.9992545,0.000155024,0.00006954026,0.0001692991,0.0001810733,0.0001705203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001332149,0.0002610621,0.0000352897,0.0004652829,0.000122598,0.000008343552,0.001187194,0.001703733,0.9884198,0.00002175975,0.001407037,0.00503578],"study_design_scores_gemma":[0.001047858,0.0007786421,0.0006041396,0.0007426599,0.0001112856,0.000001517803,0.000121264,0.003203164,0.9914603,0.00003364752,0.001687196,0.0002083829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952233,0.0002041212,0.0007295026,0.0008960258,0.001290002,0.001042141,0.00005782601,0.00009740837,0.0004596708],"genre_scores_gemma":[0.9966857,0.00002351807,0.0006887613,0.0002879018,0.000160353,0.0001220028,0.00004708386,0.00004568223,0.001939019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004827397,"threshold_uncertainty_score":0.9986513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010118492305426,"score_gpt":0.2635605022534344,"score_spread":0.2434593173303801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}