{"id":"W4392588461","doi":"10.3390/cells13060480","title":"Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Queen's University","funders":"Health Canada; Harvard Stem Cell Institute; Natural Sciences and Engineering Research Council of Canada; Queen's University","keywords":"G protein-coupled receptor; Functional selectivity; Receptor; Allosteric regulation; Cannabinoid receptor; Signal transduction; Chemistry; Cell biology; Crosstalk; Cannabinoid; Cannabinoid Receptor Agonists; Allosteric modulator; Cell signaling; Biology; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001428584,0.0002466031,0.00023019,0.0001456526,0.0001530436,0.0002527066,0.0001661004,0.0002159398,0.001164458],"category_scores_gemma":[0.00009739372,0.0001165453,0.0002764456,0.0001767581,0.0001125396,0.0001492925,0.0001425249,0.0004482092,0.0003258798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973287,"about_ca_system_score_gemma":0.0002729435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00153576,"about_ca_topic_score_gemma":0.002611027,"domain_scores_codex":[0.9997975,0.00003471014,0.00001765053,0.00002622288,0.00005583289,0.00006814411],"domain_scores_gemma":[0.9999679,0.000006402646,0.000004827876,0.00000523247,0.000007377354,0.000008199105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007295089,0.00003034681,0.00008706334,0.00002494447,0.000003038589,0.00002510216,0.00001314027,0.00006322997,0.998711,0.0001140133,0.00004297237,0.0008120573],"study_design_scores_gemma":[0.0000118589,0.0002254089,0.001678819,0.000003262942,0.00001097563,0.00008194744,0.00002304331,0.0008435307,0.9961527,0.00002586906,0.0009389253,0.000003641759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938724,0.00131331,0.001472772,0.000112129,0.00003401511,0.00003429363,0.000314407,0.00003762656,0.002809082],"genre_scores_gemma":[0.9950762,0.001038024,0.001638973,0.00006189779,0.000006082798,0.00003586646,0.0002873593,0.000007555321,0.001848018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00153576,"threshold_uncertainty_score":0.003895521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02010118492305426,"score_gpt":0.2635605022534344,"score_spread":0.2434593173303801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}