{"id":"W4392591875","doi":"10.1101/2024.03.04.583404","title":"EDC-3 and EDC-4 Regulate Embryonic mRNA Clearance and Biomolecular Condensate Specialization","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; McGill University","keywords":"Embryonic stem cell; Messenger RNA; Cell biology; P-bodies; Embryogenesis; Ubiquitin ligase; Stress granule; Embryo; Maternal to zygotic transition; Cytosol; RNA; Ubiquitin; Biology; Chemistry; Zygote; Genetics; Translation (biology); Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000158699,0.00030384,0.0001931553,0.000218589,0.0002184921,0.0004357998,0.0002346993,0.0002909806,0.001609715],"category_scores_gemma":[0.0001444188,0.0001733865,0.000202579,0.00009138405,0.0003232241,0.0001982205,0.0004704951,0.0004627762,0.000382062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006703294,"about_ca_system_score_gemma":0.0003288663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009392349,"about_ca_topic_score_gemma":0.001321389,"domain_scores_codex":[0.9998608,0.000009932207,0.000008569973,0.00003551281,0.00004294674,0.00004224641],"domain_scores_gemma":[0.9998584,0.00001814761,0.00004388772,0.00001510292,0.00002242816,0.00004209197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008412232,0.000007636155,0.0005573387,0.00002048601,0.00000348442,0.00005296086,0.000005949312,0.0001445406,0.9978331,0.0003219321,0.00006623472,0.0009023072],"study_design_scores_gemma":[0.00001101636,0.00002399755,0.006072825,0.000004499229,0.000005444057,0.00006924955,0.00001591487,0.001914374,0.9901168,0.00008639279,0.001675793,0.000003744184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863814,0.001210397,0.008452198,0.0001614415,0.00004269469,0.00002020766,0.0005338091,0.0001762548,0.003021708],"genre_scores_gemma":[0.992247,0.0002072664,0.003134244,0.00006325736,0.000006020229,0.0000163904,0.0004789058,0.00005256241,0.003794401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001609715,"threshold_uncertainty_score":0.005385041,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008898229226468891,"score_gpt":0.234062519606636,"score_spread":0.2251642903801671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}