{"id":"W4392593517","doi":"10.1002/ange.202402123","title":"Lowering Entropic Barriers in Triplex DNA Switches Facilitating Biomedical Applications at Physiological pH","year":2024,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province; National Natural Science Foundation of China","keywords":"DNA; Chemistry; Nanotechnology; Biophysics; Materials science; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036381,0.0002417144,0.0001597752,0.0001135747,0.0001119194,0.0002838739,0.0002060325,0.0002335773,0.0007380747],"category_scores_gemma":[0.0002395897,0.0001493551,0.000121764,0.00007007556,0.000252479,0.000299403,0.0002489981,0.0003871316,0.000201275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493371,"about_ca_system_score_gemma":0.0002022767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002476002,"about_ca_topic_score_gemma":0.0003568344,"domain_scores_codex":[0.9999244,0.00001154647,0.000005973756,0.00001876274,0.00002314349,0.00001623813],"domain_scores_gemma":[0.9998904,0.00003801212,0.00003124168,0.000006153084,0.00001289585,0.00002131136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002431669,0.000005095777,0.00004390483,0.00002160077,0.000001674236,0.00001478182,0.000008276281,0.000315677,0.9984231,0.0003243361,0.00001423688,0.0008030779],"study_design_scores_gemma":[0.000006451871,0.00008166551,0.0001912665,0.000002582887,0.000003149421,0.00003228724,0.000006837997,0.002370328,0.9965054,0.0000832373,0.0007126923,0.000004145375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780589,0.0008092636,0.01938214,0.00009981333,0.00003418447,0.00003173142,0.00006613914,0.0001212545,0.001396613],"genre_scores_gemma":[0.9938433,0.0003370073,0.004690508,0.00005220331,0.000007199025,0.00003026036,0.00004064284,0.00001421602,0.0009845791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007380747,"threshold_uncertainty_score":0.002469122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01088340430076233,"score_gpt":0.2507454515623357,"score_spread":0.2398620472615733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}