{"id":"W4392597209","doi":"10.1093/jleuko/qiae051","title":"Biologic therapy in rare eosinophil-associated disorders: remaining questions and translational research opportunities","year":2024,"lang":"en","type":"review","venue":"Journal of Leukocyte Biology","topic":"Eosinophilic Disorders and Syndromes","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NHLBI Division of Intramural Research; National Center for Advancing Translational Sciences; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; GlaxoSmithKline; National Heart, Lung, and Blood Institute; Fonds De La Recherche Scientifique - FNRS; AstraZeneca","keywords":"Hypereosinophilia; Eosinophil; Clinical trial; Eosinophilic; Medicine; Intensive care medicine; Granulomatosis with polyangiitis; Translational research; Disease; Rare disease; Internal medicine; Immunology; Eosinophilia; Pathology; Vasculitis; Asthma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02654528,0.001067765,0.003511041,0.001979787,0.001163247,0.00617251,0.002439796,0.007150994,0.006202048],"category_scores_gemma":[0.02288987,0.000564584,0.002421692,0.00199002,0.003807233,0.01090931,0.002435497,0.00873038,0.001882839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002139941,"about_ca_system_score_gemma":0.007795447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001235511,"about_ca_topic_score_gemma":0.002584514,"domain_scores_codex":[0.994399,0.002496285,0.001135312,0.000480486,0.0009624896,0.0005264957],"domain_scores_gemma":[0.9399468,0.04598767,0.002572119,0.001854954,0.007493319,0.002145024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008463915,0.0005893988,0.00136462,0.01236296,0.0002763557,0.0006841728,0.0005560732,0.001168663,0.001680153,0.02354671,0.04738933,0.9095351],"study_design_scores_gemma":[0.0004856824,0.002241591,0.003149725,0.03346938,0.0008309423,0.002158573,0.002301648,0.001915169,0.001421934,0.0626627,0.8891587,0.0002041023],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007230272,0.9573213,0.0009205568,0.03802278,0.001631674,0.00002383124,0.00006078839,0.00003511284,0.001260942],"genre_scores_gemma":[0.007036637,0.9606965,0.004224314,0.0165971,0.01057042,0.000106855,0.0001934724,0.00002703114,0.0005475885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02654528,"threshold_uncertainty_score":0.1403865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3874531548707227,"score_gpt":0.4824277418299371,"score_spread":0.0949745869592144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}