{"id":"W4392597295","doi":"10.3390/gels10030186","title":"A Fully Integrated Microfluidic Device with Immobilized Dyes for Simultaneous Detection of Cell-Free DNA and Histones from Plasma Using Dehydrated Agarose Gates","year":2024,"lang":"en","type":"article","venue":"Gels","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Histone; Microfluidics; Sepsis; Agarose; Biomarker; genomic DNA; Lab-on-a-chip; DNA; Chemistry; Computational biology; Chromatography; Biology; Nanotechnology; Materials science; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006672515,0.0002011671,0.0003636512,0.0001209502,0.00006142508,0.00004048599,0.00004644067,0.00009443393,0.00002857423],"category_scores_gemma":[0.0001160378,0.0001400218,0.00006985469,0.0002163959,0.00007350927,0.00005349581,0.00002062113,0.00007526724,0.000003882825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001463601,"about_ca_system_score_gemma":0.0001052689,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009722848,"about_ca_topic_score_gemma":0.0001861279,"domain_scores_codex":[0.9990868,0.00002762236,0.0002564429,0.0003358102,0.0001174614,0.0001758415],"domain_scores_gemma":[0.9988692,0.0006169468,0.00007181715,0.0002103705,0.0001542323,0.0000773754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008558082,0.0002105224,0.0006330404,0.0002429412,0.0002867288,0.0001091015,0.0005616813,0.00002130345,0.9901648,0.000002647697,0.0001015304,0.006809855],"study_design_scores_gemma":[0.00317488,0.0009180356,0.0002888759,0.0006109243,0.0008699923,0.00006963241,0.0003968147,0.008981173,0.9823931,0.00005849245,0.002094197,0.0001438166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820893,0.01620273,0.0005225248,0.0001098646,0.0001355104,0.0007053869,0.0001246,0.00009188651,0.00001817005],"genre_scores_gemma":[0.9972374,0.0003682142,0.002041591,0.00005316408,0.00004265369,0.00006927965,0.00007889231,0.00003980013,0.0000690299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01583451,"threshold_uncertainty_score":0.5709922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0346001361963065,"score_gpt":0.2888631646468601,"score_spread":0.2542630284505536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}