{"id":"W4392600366","doi":"10.1016/j.xcrm.2024.101465","title":"Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell therapy","year":2024,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Princess Margaret Cancer Foundation","keywords":"Cell biology; Ex vivo; Cell therapy; Chemistry; Biophysics; Biology; Stem cell; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000110012,0.0003336816,0.0002024181,0.0001355345,0.00007824202,0.0002312214,0.0001158144,0.0002356352,0.001091074],"category_scores_gemma":[0.00005030393,0.00006816406,0.00015592,0.00008024518,0.0001371314,0.0001334951,0.0001541467,0.0004603636,0.0001887775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001358663,"about_ca_system_score_gemma":0.0001206426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001366331,"about_ca_topic_score_gemma":0.0004577551,"domain_scores_codex":[0.9999188,0.00001979055,0.000005534003,0.00001445305,0.0000215831,0.00001992706],"domain_scores_gemma":[0.999965,0.000005763379,0.00001043651,0.000005161305,0.000002793558,0.00001091725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001320676,0.0000278514,0.00009507393,0.00002699234,0.000003683647,0.0000262571,0.000007783525,0.000116762,0.9980935,0.00006668032,0.00003078758,0.001372529],"study_design_scores_gemma":[0.00002294095,0.0004928454,0.000972399,0.000003888149,0.00001195061,0.0001243804,0.00001350076,0.0005184711,0.9956726,0.00003998607,0.0021249,0.000002153657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921997,0.001506961,0.003887957,0.0001306051,0.00004737043,0.00004837688,0.0002820191,0.00009635408,0.001800732],"genre_scores_gemma":[0.9961278,0.0005564745,0.001906517,0.00004618343,0.00001178765,0.0000338958,0.0001503983,0.00000940122,0.001157509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001091074,"threshold_uncertainty_score":0.00364995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03027483788528309,"score_gpt":0.3158685303698254,"score_spread":0.2855936924845423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}