{"id":"W4392604216","doi":"10.1101/2024.03.05.583524","title":"Atypical Cell Cycle Regulation Promotes Mammary Stem Cell Expansion and Therapeutic Resistance","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Windsor","funders":"University of Windsor","keywords":"Stem cell; Cell biology; Resistance (ecology); Cell cycle; Cell; Biology; Cancer research; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070015,0.0002083772,0.0002715668,0.0003009909,0.0001092511,0.0002926381,0.0001293168,0.0003386366,0.001660338],"category_scores_gemma":[0.0001102375,0.0001199957,0.00016645,0.0001254073,0.000202145,0.0001514911,0.000238838,0.0006882558,0.0002870248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448675,"about_ca_system_score_gemma":0.0001367403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001662184,"about_ca_topic_score_gemma":0.0002356911,"domain_scores_codex":[0.9998561,0.00001792045,0.00001157439,0.00003129309,0.00004912298,0.00003399159],"domain_scores_gemma":[0.999772,0.0000313507,0.0000857507,0.00002253621,0.00001959547,0.00006888048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008091173,0.00002164085,0.0003612838,0.00001537002,0.000002610695,0.00003865231,0.000004185626,0.00005078599,0.9984238,0.00005428972,0.00002988306,0.0009165625],"study_design_scores_gemma":[0.00001771222,0.0005595252,0.01199491,0.000004942779,0.00001199427,0.0005260475,0.00002224493,0.001226086,0.983648,0.0001020793,0.001882629,0.00000395963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968055,0.00103286,0.001094754,0.00008219117,0.0000131277,0.00001967695,0.000182156,0.00008074424,0.000689022],"genre_scores_gemma":[0.9978624,0.0003155244,0.0005667547,0.00002924739,0.000007089124,0.00001742196,0.0001696531,0.00001066473,0.001021173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001660338,"threshold_uncertainty_score":0.005554438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01363564879588095,"score_gpt":0.2235920664363095,"score_spread":0.2099564176404286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}