{"id":"W4392615010","doi":"10.1093/ibd/izae024","title":"Two-Year Efficacy and Safety of Mirikizumab Following 104 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study","year":2024,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University Health Centre","funders":"Genentech; Pfizer; Vifor Pharma; Amgen; Tillotts Pharma; United European Gastroenterology; Celltrion; Celgene; Biogen; Janssen Pharmaceuticals; Gilead Sciences; Eli Lilly and Company; Bristol-Myers Squibb; Falk Foundation","keywords":"Ulcerative colitis; Open label; Medicine; Internal medicine; Gastroenterology; Extension (predicate logic); Adverse effect; Disease; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003603576,0.001046383,0.001703682,0.0004341527,0.0004374782,0.0007306231,0.0006976421,0.00117502,0.001526552],"category_scores_gemma":[0.002043494,0.0003398309,0.001672992,0.0003508627,0.0005980899,0.000879225,0.0004361541,0.002128963,0.000658991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007009592,"about_ca_system_score_gemma":0.0005536616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008102128,"about_ca_topic_score_gemma":0.0009924703,"domain_scores_codex":[0.9989474,0.0004937229,0.00007087434,0.000140785,0.0001506666,0.0001965777],"domain_scores_gemma":[0.9975926,0.0003833525,0.0009379333,0.0003127131,0.0001712698,0.0006020689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7660855,0.04438822,0.0504699,0.0004662107,0.001804351,0.000366374,0.000442656,0.001767361,0.02686125,0.00005806788,0.001507861,0.1057821],"study_design_scores_gemma":[0.1230033,0.5282509,0.3393861,0.00005280282,0.001294275,0.0003753444,0.00009265063,0.001882156,0.003937905,0.00007214909,0.001576052,0.00007628738],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984483,0.0004946295,0.0001710093,0.00004131911,0.00001196827,0.0001957564,0.0003130494,0.00003667142,0.0002872278],"genre_scores_gemma":[0.9969251,0.0002247612,0.0003969453,0.0001333785,0.00005183711,0.0003115026,0.001257594,0.00001053428,0.0006884028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003603576,"threshold_uncertainty_score":0.01905775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181372466786241,"score_gpt":0.2953979266882808,"score_spread":0.2772606800096567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}