{"id":"W4392619716","doi":"10.1093/jac/dkae057","title":"Pharmacokinetics and pharmacodynamics of high-dose isoniazid for the treatment of rifampicin- or multidrug-resistant tuberculosis in Indonesia","year":2024,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Universitas Padjadjaran","keywords":"Cmax; Isoniazid; Pharmacokinetics; Medicine; Rifampicin; Pharmacology; Tuberculosis; Pharmacodynamics; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000434616,0.0001400647,0.0002657097,0.0001155578,0.00009601932,0.0002782673,0.0001347976,0.00009447947,0.0004218241],"category_scores_gemma":[0.0008347171,0.0001190794,0.0001612612,0.0001460498,0.0001456409,0.0001684401,0.000113019,0.0003014389,0.0001191644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478106,"about_ca_system_score_gemma":0.0002784586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009513979,"about_ca_topic_score_gemma":0.0009728377,"domain_scores_codex":[0.9998566,0.00004675573,0.00001949215,0.00003179682,0.00003112785,0.00001415158],"domain_scores_gemma":[0.9996294,0.00009032516,0.0001717351,0.00002211172,0.00003222222,0.00005423126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003139862,0.0008008064,0.9443216,0.0001383202,0.00009719661,0.0004521097,0.0002995777,0.001080524,0.01852369,0.00005882961,0.0002110154,0.03087659],"study_design_scores_gemma":[0.00008239536,0.001775068,0.9922671,0.000007755641,0.00004989469,0.001182358,0.00009971485,0.001833636,0.00219524,0.00003968078,0.0004613526,0.000005843556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992586,0.0002312717,0.0002194997,0.00002824347,0.000001826363,0.00001023728,0.00005630512,0.000004814322,0.0001892339],"genre_scores_gemma":[0.9994104,0.0001419875,0.0002404802,0.00002381696,0.000003690217,0.000008605941,0.00006970197,0.000001763546,0.00009953325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009513979,"threshold_uncertainty_score":0.002523541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02490669045614856,"score_gpt":0.3547880687328188,"score_spread":0.3298813782766702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}